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Volume 28 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(2): 112-113,125

CAI Bin-xin, GUO Yu-feng, ZHANG Zhi, XIAO Liang, ZHANG Li-ming. Effects of tentacle-only extract from jellyfish Cyanea capillata on the conduction system of isolated rat heart[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 112-113,125.
Citation: CAI Bin-xin, GUO Yu-feng, ZHANG Zhi, XIAO Liang, ZHANG Li-ming. Effects of tentacle-only extract from jellyfish Cyanea capillata on the conduction system of isolated rat heart[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 112-113,125.
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Effects of tentacle-only extract from jellyfish Cyanea capillata on the conduction system of isolated rat heart

  • Department of Chemical Defense Medicine,Faculty of Naval Medicine,Second Military Medical University,Shanghai 200433,China

  • Received Date: 2010-03-02
  • Rev Recd Date: 2010-03-16
  • Objective To observe the effects of tentacle-only extract(TOE) from Cyanea capillata on the conduction system of isolated rat heart and investigate the mechanism of its cardiac toxicity. Methods Seventy-two Sprague Dawley(SD) rats were randomly divided into six groups(n=12),and Langendorff heart perfusion models were established,then different doses of TOE were applied to each group to observe the effects of TOE on the conduction system of the isolated rat hearts. Results Compared with the control group,all the doses of TOE induced a significant decrease of heart rate,and the incidence of arrhythmia was significantly increased.Moreover,both the effects were dose-dependent. Conclusion The TOE of C.capillata induced significant changes of the conduction system of isolated rat heart,which could partly interpret the mechanism of its cardiac toxicity.
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Effects of tentacle-only extract from jellyfish Cyanea capillata on the conduction system of isolated rat heart

  • Department of Chemical Defense Medicine,Faculty of Naval Medicine,Second Military Medical University,Shanghai 200433,China
  • Received Date: 2010-03-02
  • Rev Recd Date: 2010-03-16

Abstract: Objective To observe the effects of tentacle-only extract(TOE) from Cyanea capillata on the conduction system of isolated rat heart and investigate the mechanism of its cardiac toxicity. Methods Seventy-two Sprague Dawley(SD) rats were randomly divided into six groups(n=12),and Langendorff heart perfusion models were established,then different doses of TOE were applied to each group to observe the effects of TOE on the conduction system of the isolated rat hearts. Results Compared with the control group,all the doses of TOE induced a significant decrease of heart rate,and the incidence of arrhythmia was significantly increased.Moreover,both the effects were dose-dependent. Conclusion The TOE of C.capillata induced significant changes of the conduction system of isolated rat heart,which could partly interpret the mechanism of its cardiac toxicity.

CAI Bin-xin, GUO Yu-feng, ZHANG Zhi, XIAO Liang, ZHANG Li-ming. Effects of tentacle-only extract from jellyfish Cyanea capillata on the conduction system of isolated rat heart[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 112-113,125.
Citation: CAI Bin-xin, GUO Yu-feng, ZHANG Zhi, XIAO Liang, ZHANG Li-ming. Effects of tentacle-only extract from jellyfish Cyanea capillata on the conduction system of isolated rat heart[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 112-113,125.
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