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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(1): 40-42

QIU Cai-rong, LI Xin-tian, LIN Yu, CHEN Chong-shang. Determination of sinomenine in Wuten Zhentong capsules by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 40-42.
Citation: QIU Cai-rong, LI Xin-tian, LIN Yu, CHEN Chong-shang. Determination of sinomenine in Wuten Zhentong capsules by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 40-42.
shu

Determination of sinomenine in Wuten Zhentong capsules by HPLC

  • 1.

    Department of Pharmacy,No.3 Hospital of PLA,Baoji 721004,China

  • 2.

    Shanxi Sheng zhu Phar.Sci and Tech Co.Ltd.,Xi’an 710054,China

  • Received Date: 2009-06-22
  • Rev Recd Date: 2009-11-08
  • Objective To establish an HPLC method for determining the content of sinomenine in Wuten Zhentong capsule. Methods The sample was analyzed on a Shim-pack CLC-ODS-C18(150 mm×4.6 mm,5 μm) column using methanol-phosphate buffer(5 mmol/L sodium hydrogen phosphate solution,adjust pH to 8.0 using 5 mmol/L sodium hypophosphite solution and then adjust pH to 9.0 using 1% triethylamine solution)(5545) as mobile phase at 25℃.The detection wavelength was 262 nm and flow rate 1.0 ml/min. Results Good linearity was shown within the range of 0.92～4.60 μg,the correlation coefficient(r) was 0.999 6,the average recovery rate was 99.21%with RSD of 0.61%(n=6). Conclusion The Results demonstrated that the analytical Methods used for the content determination were reproducible,feasible,convenient and easily performable,which can be adopted as the standard Methods for the quality control of the Wuten Zhentong capsule.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of sinomenine in Wuten Zhentong capsules by HPLC

  • 1. Department of Pharmacy,No.3 Hospital of PLA,Baoji 721004,China
  • 2. Shanxi Sheng zhu Phar.Sci and Tech Co.Ltd.,Xi’an 710054,China
  • Received Date: 2009-06-22
  • Rev Recd Date: 2009-11-08

Abstract: Objective To establish an HPLC method for determining the content of sinomenine in Wuten Zhentong capsule. Methods The sample was analyzed on a Shim-pack CLC-ODS-C18(150 mm×4.6 mm,5 μm) column using methanol-phosphate buffer(5 mmol/L sodium hydrogen phosphate solution,adjust pH to 8.0 using 5 mmol/L sodium hypophosphite solution and then adjust pH to 9.0 using 1% triethylamine solution)(5545) as mobile phase at 25℃.The detection wavelength was 262 nm and flow rate 1.0 ml/min. Results Good linearity was shown within the range of 0.92～4.60 μg,the correlation coefficient(r) was 0.999 6,the average recovery rate was 99.21%with RSD of 0.61%(n=6). Conclusion The Results demonstrated that the analytical Methods used for the content determination were reproducible,feasible,convenient and easily performable,which can be adopted as the standard Methods for the quality control of the Wuten Zhentong capsule.

QIU Cai-rong, LI Xin-tian, LIN Yu, CHEN Chong-shang. Determination of sinomenine in Wuten Zhentong capsules by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 40-42.
Citation: QIU Cai-rong, LI Xin-tian, LIN Yu, CHEN Chong-shang. Determination of sinomenine in Wuten Zhentong capsules by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 40-42.
shu

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