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Volume 28 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(1): 23-24,72

SUN Ting, ZOU Ying-xin, ZHENG Jie-min, HUANG Mao, ZHANG Xiao-dong. Effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 23-24,72.
Citation: SUN Ting, ZOU Ying-xin, ZHENG Jie-min, HUANG Mao, ZHANG Xiao-dong. Effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 23-24,72.
shu

Effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice

  • 1.

    Department of Pharmacy,Navy General Hospital,Beijing 100048,China

  • 2.

    Center of New Drug Evaluation,Second Military Medical University,Shanghai 200433,China

  • Received Date: 2009-06-25
  • Rev Recd Date: 2009-10-26
  • Objective To observe the effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice. Methods Male mice were used as subjects.Total range of motion after treated with morphine and haloperidol were evaluated by locomotion activity video analysis system.Total range of motion,average velocity and number of shuttle were also evaluated after the psychical dependence established. Results Distance travelled was significantly increased after administration of morphine.Distance travelled was significantly decreased in haloperidol group.Haloperidol could intercept hyperlocomotion induced by morphine.After treated with morphine,time to the morphine side significantly increased.Distance travelled,average velocity and number of shuttle also decreased significantly. Conclusion Haloperidol could suppress behavioral sensitization induced by morphine.The dopamine system functions may be inhibited after conditioned place preference established.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice

  • 1. Department of Pharmacy,Navy General Hospital,Beijing 100048,China
  • 2. Center of New Drug Evaluation,Second Military Medical University,Shanghai 200433,China
  • Received Date: 2009-06-25
  • Rev Recd Date: 2009-10-26

Abstract: Objective To observe the effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice. Methods Male mice were used as subjects.Total range of motion after treated with morphine and haloperidol were evaluated by locomotion activity video analysis system.Total range of motion,average velocity and number of shuttle were also evaluated after the psychical dependence established. Results Distance travelled was significantly increased after administration of morphine.Distance travelled was significantly decreased in haloperidol group.Haloperidol could intercept hyperlocomotion induced by morphine.After treated with morphine,time to the morphine side significantly increased.Distance travelled,average velocity and number of shuttle also decreased significantly. Conclusion Haloperidol could suppress behavioral sensitization induced by morphine.The dopamine system functions may be inhibited after conditioned place preference established.

SUN Ting, ZOU Ying-xin, ZHENG Jie-min, HUANG Mao, ZHANG Xiao-dong. Effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 23-24,72.
Citation: SUN Ting, ZOU Ying-xin, ZHENG Jie-min, HUANG Mao, ZHANG Xiao-dong. Effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 23-24,72.
shu

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