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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(6): 426-429

WU Guang, LIU Jia, NIU Chun-Juan, LI Ke. Synthesis and antiviral activities of substituted adenine analogues on HBV[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 426-429.
Citation: WU Guang, LIU Jia, NIU Chun-Juan, LI Ke. Synthesis and antiviral activities of substituted adenine analogues on HBV[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 426-429.
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Synthesis and antiviral activities of substituted adenine analogues on HBV

  • Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2009-03-17
  • Objective :To study of design and synthesis of the new(ADV) derivatives and study their activities of inhibiting hepatitis B virus HBsAg and HBeAg. Methods :Starting with ADV,we synthesized 8 firstly reported purine compounds 1a-1h,which have been verified by NMR and MS.Enzyme-linked immunosorbent assay(ELISA) was used to assess HBsAg and HBeAg.The positive control is ADV. Results :The test results show the inhibitory rate of targeted purine compounds on HBsAg nad HBeAg is correspond with ADV. Conclusion :1g introduced long carbon chain at N6 substituted of purine shows the best activity.
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Synthesis and antiviral activities of substituted adenine analogues on HBV

  • Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2009-03-17

Abstract: Objective :To study of design and synthesis of the new(ADV) derivatives and study their activities of inhibiting hepatitis B virus HBsAg and HBeAg. Methods :Starting with ADV,we synthesized 8 firstly reported purine compounds 1a-1h,which have been verified by NMR and MS.Enzyme-linked immunosorbent assay(ELISA) was used to assess HBsAg and HBeAg.The positive control is ADV. Results :The test results show the inhibitory rate of targeted purine compounds on HBsAg nad HBeAg is correspond with ADV. Conclusion :1g introduced long carbon chain at N6 substituted of purine shows the best activity.

WU Guang, LIU Jia, NIU Chun-Juan, LI Ke. Synthesis and antiviral activities of substituted adenine analogues on HBV[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 426-429.
Citation: WU Guang, LIU Jia, NIU Chun-Juan, LI Ke. Synthesis and antiviral activities of substituted adenine analogues on HBV[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 426-429.
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