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Volume 27 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(5): 365-366,387

CAI Lin, YAN Ju-jiao, LI Heng. Determination of residual solvents in gatifloxacin by headspace capillary gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 365-366,387.
Citation: CAI Lin, YAN Ju-jiao, LI Heng. Determination of residual solvents in gatifloxacin by headspace capillary gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 365-366,387.
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Determination of residual solvents in gatifloxacin by headspace capillary gas chromatography

  • 1.

    181th Hospital of Chinese People's Libration Army, Guilin 541002, China

  • 2.

    Wuhan Institute for Drug Control, Wuhan 430012, China

  • Received Date: 2009-08-16
  • Objective :To establish a method for determination of five residual solvents in gatifloxacin. Methods : The residual organic solvents which are ethanol,acetonitrile,dichloromethane,ethyl acetate,toluene were quantitatively determined by headspace GC on DM-624 column,90%DMF as solvent media,with FID detector,high purity nitrogen as the carrier gas. Results : Five residual solvents were completely separated.There was a good linearity(r=0.999 7～0.999 9).The detection limit of ethanol,acetonitrile,Dichloromethane,ethyl acetate,toluene were all less than 3μg/g;the RSD of precision was less than 5%;the average recovery rate of the preparation was in the range of 94.8%～98.6%. Conclusion :The method is simple,rapid,sensitive and can be used for the quality control of gatifloxacin.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of residual solvents in gatifloxacin by headspace capillary gas chromatography

  • 1. 181th Hospital of Chinese People's Libration Army, Guilin 541002, China
  • 2. Wuhan Institute for Drug Control, Wuhan 430012, China
  • Received Date: 2009-08-16

Abstract: Objective :To establish a method for determination of five residual solvents in gatifloxacin. Methods : The residual organic solvents which are ethanol,acetonitrile,dichloromethane,ethyl acetate,toluene were quantitatively determined by headspace GC on DM-624 column,90%DMF as solvent media,with FID detector,high purity nitrogen as the carrier gas. Results : Five residual solvents were completely separated.There was a good linearity(r=0.999 7～0.999 9).The detection limit of ethanol,acetonitrile,Dichloromethane,ethyl acetate,toluene were all less than 3μg/g;the RSD of precision was less than 5%;the average recovery rate of the preparation was in the range of 94.8%～98.6%. Conclusion :The method is simple,rapid,sensitive and can be used for the quality control of gatifloxacin.

CAI Lin, YAN Ju-jiao, LI Heng. Determination of residual solvents in gatifloxacin by headspace capillary gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 365-366,387.
Citation: CAI Lin, YAN Ju-jiao, LI Heng. Determination of residual solvents in gatifloxacin by headspace capillary gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 365-366,387.
shu

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