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Volume 27 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(5): 334-336,352

WANG Ke-bing, ZOU Li-hua, ZHANG Zhi-qiang. Therapeutical effects of Danhong for injection on myocardial infarction in dogs[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 334-336,352.
Citation: WANG Ke-bing, ZOU Li-hua, ZHANG Zhi-qiang. Therapeutical effects of Danhong for injection on myocardial infarction in dogs[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 334-336,352.
shu

Therapeutical effects of Danhong for injection on myocardial infarction in dogs

  • 1.

    Department of pharmacy, 169th Hospital of PLA, Hengyang 421002, China

  • 2.

    Health Care Department of Management and Logistic Support Department, Headquartes' of General Staff, PLA, Beijing 100082, China

  • 3.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2009-04-29
  • Objective :To investigate the therapeutical effects of Danhong for injection on myocardial infarction model induced by coronary artery ligation in dogs. Methods : The models of myocardial infarction were produced by ligation of the left anterior descending coronary artery in the anaesthetized dogs.The extent of myocardial ischemia and infarction was determined by means of epicardial mapping and N-BT staining.The parameters of lactate dehydrogenase and creatine kinase were also determined in the serums of dogs. Results :Danhong for injection(2、6 and 12mg/kg) by the way of intravenous injection obviously reduced the extent of myocardial infarction and the myocardial ischemia level at a dose-dependent manner.Increase of ∑-ST and N-ST,and the range of myocardial infarction caused by ligating coronary artery in dogs were obviously reduced by Danhong for injection.The level of LDH and CK in the serum of dogs were also decreased by Danhong for injection.Conclusions:The results show that Danhong for injection has significant protective effects on myocardial infarction in dogs.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Therapeutical effects of Danhong for injection on myocardial infarction in dogs

  • 1. Department of pharmacy, 169th Hospital of PLA, Hengyang 421002, China
  • 2. Health Care Department of Management and Logistic Support Department, Headquartes' of General Staff, PLA, Beijing 100082, China
  • 3. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2009-04-29

Abstract: Objective :To investigate the therapeutical effects of Danhong for injection on myocardial infarction model induced by coronary artery ligation in dogs. Methods : The models of myocardial infarction were produced by ligation of the left anterior descending coronary artery in the anaesthetized dogs.The extent of myocardial ischemia and infarction was determined by means of epicardial mapping and N-BT staining.The parameters of lactate dehydrogenase and creatine kinase were also determined in the serums of dogs. Results :Danhong for injection(2、6 and 12mg/kg) by the way of intravenous injection obviously reduced the extent of myocardial infarction and the myocardial ischemia level at a dose-dependent manner.Increase of ∑-ST and N-ST,and the range of myocardial infarction caused by ligating coronary artery in dogs were obviously reduced by Danhong for injection.The level of LDH and CK in the serum of dogs were also decreased by Danhong for injection.Conclusions:The results show that Danhong for injection has significant protective effects on myocardial infarction in dogs.

WANG Ke-bing, ZOU Li-hua, ZHANG Zhi-qiang. Therapeutical effects of Danhong for injection on myocardial infarction in dogs[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 334-336,352.
Citation: WANG Ke-bing, ZOU Li-hua, ZHANG Zhi-qiang. Therapeutical effects of Danhong for injection on myocardial infarction in dogs[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 334-336,352.
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