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Volume 27 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(3): 179-182,217

LIU Zhi-rui, YE Xian-cheng, WANG Fang, ZHANG Ning, FAN Xu-yan, LU Ying, ZHONG Yan-qiang, ZOU Hao. Studies on orally disintegrating tablet of caffeine[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 179-182,217.
Citation: LIU Zhi-rui, YE Xian-cheng, WANG Fang, ZHANG Ning, FAN Xu-yan, LU Ying, ZHONG Yan-qiang, ZOU Hao. Studies on orally disintegrating tablet of caffeine[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 179-182,217.
shu

Studies on orally disintegrating tablet of caffeine

  • 1.

    School of pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Department of pharmacy, Tongji Hospital of Tongji University, Shanghai 200065, China

  • 3.

    Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, 200135, China

  • Received Date: 2008-09-16
  • Objective :To optimize the formula of caffeine orally disintegrating tablet and to investigate the related indexes. Methods :Taking the contents of L-HPC,MCC(disintegrating agent)as disintegrants and the disintegrating time(td)as evaluation indexes to carry out the orthogonal experiment to optimize the formula.The dissolution curve of the optimized formula was drawn. Results :The optimized formula for caffeine orally disintegrating tablet was as follows:the contents of caffeine,MCC,L-HPC,and mannitol were 100,40,25,and 105 mg,respectively.The prepared orally disintegrating tablets disintegrated completely within 30 s and dissolved basically within 2 min. Conclusion :This preparation method of oralhy disintegranting tablet of caffeine is simple and available.Determination method has high accuracy and recovery.It is a suitable method for the preparation and content determination of caffeine orally disintegranting tablet.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Studies on orally disintegrating tablet of caffeine

  • 1. School of pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. Department of pharmacy, Tongji Hospital of Tongji University, Shanghai 200065, China
  • 3. Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, 200135, China
  • Received Date: 2008-09-16

Abstract: Objective :To optimize the formula of caffeine orally disintegrating tablet and to investigate the related indexes. Methods :Taking the contents of L-HPC,MCC(disintegrating agent)as disintegrants and the disintegrating time(td)as evaluation indexes to carry out the orthogonal experiment to optimize the formula.The dissolution curve of the optimized formula was drawn. Results :The optimized formula for caffeine orally disintegrating tablet was as follows:the contents of caffeine,MCC,L-HPC,and mannitol were 100,40,25,and 105 mg,respectively.The prepared orally disintegrating tablets disintegrated completely within 30 s and dissolved basically within 2 min. Conclusion :This preparation method of oralhy disintegranting tablet of caffeine is simple and available.Determination method has high accuracy and recovery.It is a suitable method for the preparation and content determination of caffeine orally disintegranting tablet.

LIU Zhi-rui, YE Xian-cheng, WANG Fang, ZHANG Ning, FAN Xu-yan, LU Ying, ZHONG Yan-qiang, ZOU Hao. Studies on orally disintegrating tablet of caffeine[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 179-182,217.
Citation: LIU Zhi-rui, YE Xian-cheng, WANG Fang, ZHANG Ning, FAN Xu-yan, LU Ying, ZHONG Yan-qiang, ZOU Hao. Studies on orally disintegrating tablet of caffeine[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 179-182,217.
shu

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