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Volume 27 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(1): 33-37

LIU Chang-hai, ZHAO Liang, ZHANG Hai, ZHU Zhen-yu, ZHANG Guo-qing, CHAI Yi-feng. Analysis of optical impurity of ephedrine levorotatory by capillary electrophoresis[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(1): 33-37.
Citation: LIU Chang-hai, ZHAO Liang, ZHANG Hai, ZHU Zhen-yu, ZHANG Guo-qing, CHAI Yi-feng. Analysis of optical impurity of ephedrine levorotatory by capillary electrophoresis[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(1): 33-37.
shu

Analysis of optical impurity of ephedrine levorotatory by capillary electrophoresis

  • 1.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2008-10-14
  • Objective : To develop a method for purity test and enantioseparation of ephedrine levorotatory by capillary electrophoresis(CE). Methods : The cyclodextrin,concentration,pH,organic solvent were studied,and the results indicated that the enantiomer of ephedrin and ephedrine levorotatory were baseline separated under the following experimental conditions:uncoated fused silica capillary(75 μm × 68 cm),25 mmol/L Tris,2% HP-β-CD and 1% SBE-β-CD,pH was adjusted at 3.0 by phosphoric acid,and 15 kV separation voltage.The detection wavelength was set at 214 nm with the column temperature of 15 ℃. Results : Under the experimental conditions adopted,the baseline separation of ephedrin and ephedrine levorotatory was obtained. Conclusions : The proposed method is simple,reliable and can be used for routine purity test and chiral separation.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Analysis of optical impurity of ephedrine levorotatory by capillary electrophoresis

  • 1. School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2008-10-14

Abstract: Objective : To develop a method for purity test and enantioseparation of ephedrine levorotatory by capillary electrophoresis(CE). Methods : The cyclodextrin,concentration,pH,organic solvent were studied,and the results indicated that the enantiomer of ephedrin and ephedrine levorotatory were baseline separated under the following experimental conditions:uncoated fused silica capillary(75 μm × 68 cm),25 mmol/L Tris,2% HP-β-CD and 1% SBE-β-CD,pH was adjusted at 3.0 by phosphoric acid,and 15 kV separation voltage.The detection wavelength was set at 214 nm with the column temperature of 15 ℃. Results : Under the experimental conditions adopted,the baseline separation of ephedrin and ephedrine levorotatory was obtained. Conclusions : The proposed method is simple,reliable and can be used for routine purity test and chiral separation.

LIU Chang-hai, ZHAO Liang, ZHANG Hai, ZHU Zhen-yu, ZHANG Guo-qing, CHAI Yi-feng. Analysis of optical impurity of ephedrine levorotatory by capillary electrophoresis[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(1): 33-37.
Citation: LIU Chang-hai, ZHAO Liang, ZHANG Hai, ZHU Zhen-yu, ZHANG Guo-qing, CHAI Yi-feng. Analysis of optical impurity of ephedrine levorotatory by capillary electrophoresis[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(1): 33-37.
shu

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