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Volume 25 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (6): 388-390

ZHENG Cheng, XIANG Zhi-min. Detection of gibenclamide and phenformin in Jiangtang capsule by liquid chromatography-electrospray Ionization tandem mass spectrometry[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 388-390.
Citation: ZHENG Cheng, XIANG Zhi-min. Detection of gibenclamide and phenformin in Jiangtang capsule by liquid chromatography-electrospray Ionization tandem mass spectrometry[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 388-390.
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Detection of gibenclamide and phenformin in Jiangtang capsule by liquid chromatography-electrospray Ionization tandem mass spectrometry

  • Zhejiang Institute for Drug Control,Hangzhou 310004,China

  • Received Date: 2007-08-16
  • Objective :To establish a liquid chromatography-electrospray ionization tandem mass spectrometry(LC-ESI-MS-MS) for the identification of glibenclamide and phenformin illegally added in Jiangtang Capsule. Methods :The detection was performed on Altima C18 column with a mobile phase of acetonitrile-formic acid solution(65-35).The above compounds were identified by LC-MS-MS. Results :Glibenclamide and phenformin were detected illegally added in one sample of Jiangtang capsule. Conclusion :This is an effective method with characteristic and sensitivity for analysis of chemical drugs added in TCM.
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Detection of gibenclamide and phenformin in Jiangtang capsule by liquid chromatography-electrospray Ionization tandem mass spectrometry

  • Zhejiang Institute for Drug Control,Hangzhou 310004,China
  • Received Date: 2007-08-16

Abstract: Objective :To establish a liquid chromatography-electrospray ionization tandem mass spectrometry(LC-ESI-MS-MS) for the identification of glibenclamide and phenformin illegally added in Jiangtang Capsule. Methods :The detection was performed on Altima C18 column with a mobile phase of acetonitrile-formic acid solution(65-35).The above compounds were identified by LC-MS-MS. Results :Glibenclamide and phenformin were detected illegally added in one sample of Jiangtang capsule. Conclusion :This is an effective method with characteristic and sensitivity for analysis of chemical drugs added in TCM.

ZHENG Cheng, XIANG Zhi-min. Detection of gibenclamide and phenformin in Jiangtang capsule by liquid chromatography-electrospray Ionization tandem mass spectrometry[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 388-390.
Citation: ZHENG Cheng, XIANG Zhi-min. Detection of gibenclamide and phenformin in Jiangtang capsule by liquid chromatography-electrospray Ionization tandem mass spectrometry[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 388-390.
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