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Volume 25 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (6): 369-371

LI Lin-peng, SUN Jun-wen, CAO Yong-bing, REN Tian-shu, JIANG Yuan-ying, SUN De-hao. Studies on the application of the hyperlipemia model of golden hamster and Wistar rat[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 369-371.
Citation: LI Lin-peng, SUN Jun-wen, CAO Yong-bing, REN Tian-shu, JIANG Yuan-ying, SUN De-hao. Studies on the application of the hyperlipemia model of golden hamster and Wistar rat[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 369-371.
shu

Studies on the application of the hyperlipemia model of golden hamster and Wistar rat

  • 1.

    Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China

  • 2.

    Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China

  • 3.

    Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China

  • Received Date: 2007-04-11
  • Objective :To compare the effect of simvastatin in the hyperlipemia model of the golden hamster and the Wistar rat,discuss the reasonable application of the two animal hyperlipemia models. Methods :Thirty male golden hamsters weighing 100-130 g and thirty male Wistar rat weighing 200-300 g were respectively randomized into 3 groups with 10 in each,named as the normal group,model group and simvastatin group.After the models of hyperlipemia were established,the simvastatin groups were treated with the dosage of 10mg/（kg·d） simvastatin.Observe the effect of simvastatin on lipid level in the 14th and 28th day.Analysed the effect of simvastatin in the two hyperlipemia models. Results :Simvastatin decreased the lipid level of the two hyperlipemia model.The effect in Wistar rat is better than in golden hamster. Conclusion : Wistar rat is more susceptible to simvastatin than golden hamster.The hyperlipemia model of Wistar rat is adapt to the application of the selection of cholesterol-lowering drugs.The hyperlipemia model of golden hamster is suit to the before clinical research of the novel cholesterol-lowering drugs.
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通讯作者: 陈斌, [email protected]
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Studies on the application of the hyperlipemia model of golden hamster and Wistar rat

  • 1. Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China
  • 2. Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China
  • 3. Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China
  • Received Date: 2007-04-11

Abstract: Objective :To compare the effect of simvastatin in the hyperlipemia model of the golden hamster and the Wistar rat,discuss the reasonable application of the two animal hyperlipemia models. Methods :Thirty male golden hamsters weighing 100-130 g and thirty male Wistar rat weighing 200-300 g were respectively randomized into 3 groups with 10 in each,named as the normal group,model group and simvastatin group.After the models of hyperlipemia were established,the simvastatin groups were treated with the dosage of 10mg/（kg·d） simvastatin.Observe the effect of simvastatin on lipid level in the 14th and 28th day.Analysed the effect of simvastatin in the two hyperlipemia models. Results :Simvastatin decreased the lipid level of the two hyperlipemia model.The effect in Wistar rat is better than in golden hamster. Conclusion : Wistar rat is more susceptible to simvastatin than golden hamster.The hyperlipemia model of Wistar rat is adapt to the application of the selection of cholesterol-lowering drugs.The hyperlipemia model of golden hamster is suit to the before clinical research of the novel cholesterol-lowering drugs.

LI Lin-peng, SUN Jun-wen, CAO Yong-bing, REN Tian-shu, JIANG Yuan-ying, SUN De-hao. Studies on the application of the hyperlipemia model of golden hamster and Wistar rat[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 369-371.
Citation: LI Lin-peng, SUN Jun-wen, CAO Yong-bing, REN Tian-shu, JIANG Yuan-ying, SUN De-hao. Studies on the application of the hyperlipemia model of golden hamster and Wistar rat[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 369-371.
shu

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