Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 25 Issue 5
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (5): 312-314,345

JIANG Jun-hang, Lü Jia-guo, ZHOU You-jun. Improvement of the synthetic process of 7-azaindol-3-carboxylic acid[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 312-314,345.
Citation: JIANG Jun-hang, Lü Jia-guo, ZHOU You-jun. Improvement of the synthetic process of 7-azaindol-3-carboxylic acid[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 312-314,345.
shu

Improvement of the synthetic process of 7-azaindol-3-carboxylic acid

  • Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2007-03-21
  • Objective : To improve the synthetic process of 7-azaindol-3-carboxylic acid. Methods : The succinonitrile was taken as the original raw material.The isopropyl ether,n-heptane,and chlorobenzene, which were used in original technics,were subsituted by ethyl acetate,petroleun ether,and xylene respectively.The disposition technics was optimized. Results : The technics was successfully improved due to its low cost,small toxicity,convenient disposition and high yield. Conclusions : The higher overall yields was 43.4%.This improved method is more suitable for industrial production for its low cost.
  • 加载中
通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2242) PDF downloads(41) Cited by()

Related
Proportional views

Improvement of the synthetic process of 7-azaindol-3-carboxylic acid

  • Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2007-03-21

Abstract: Objective : To improve the synthetic process of 7-azaindol-3-carboxylic acid. Methods : The succinonitrile was taken as the original raw material.The isopropyl ether,n-heptane,and chlorobenzene, which were used in original technics,were subsituted by ethyl acetate,petroleun ether,and xylene respectively.The disposition technics was optimized. Results : The technics was successfully improved due to its low cost,small toxicity,convenient disposition and high yield. Conclusions : The higher overall yields was 43.4%.This improved method is more suitable for industrial production for its low cost.

JIANG Jun-hang, Lü Jia-guo, ZHOU You-jun. Improvement of the synthetic process of 7-azaindol-3-carboxylic acid[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 312-314,345.
Citation: JIANG Jun-hang, Lü Jia-guo, ZHOU You-jun. Improvement of the synthetic process of 7-azaindol-3-carboxylic acid[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 312-314,345.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: [email protected]

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return