Comparison of clinical efficacy between urapidil and other vasodilators in acute left heart failure

Key words: 
• urapidil /
• vasodilators /
• acute left heart failure /
• cure

Abstract: Objective :To evaluate the clinical efficacy between urapidil and other vasodilators in acute left heart failure. Methods : 80 patients with acute left heart failure were randomly divided into 4 groups: urapidil group(n=19),phentolamine group(n=21),sodium nitroprusside group(n=16),nitroglycerin group(n=24).The change of dyspneic respiration,heart rate,blood preasure,and lung rales were recorded respectively in the process of the treatment. Results :Remission rate of dyspnea were 94.7% and 93.8% in urapidil group and sodium nitroprusside group respectively(P>0.05),nitroglycerin group was 47.7%(P<0.01).Incidence of heart rate acceleration were 66.7% and 5.3% in phentolamine group and urapidil group respectively(P<0.01).Incidence of blood pressure lowering and hypotension were 31.3% and 5.3% in sodium nitroprusside group and urapidil group respectively(P<0.05).Effective rate of reducing lung rales were 94.7% and 95.2% respectively(P>0.05),nitroglycerin group was 58.3%(P<0.05). Conclusion :The result proved that urapidil could be used as first aid for patients with acute left heart failure.