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Volume 25 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (5): 290-291

GUAN Qing-xiang, LIN Tian-mu, WANG En-si. Determination of the dissociation constant and partition coefficient of mesylate delavirdine[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 290-291.
Citation: GUAN Qing-xiang, LIN Tian-mu, WANG En-si. Determination of the dissociation constant and partition coefficient of mesylate delavirdine[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 290-291.
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Determination of the dissociation constant and partition coefficient of mesylate delavirdine

  • 1.

    School of Pharmacy, Jilin University, Changchun 130021, China;School of Life Science, Jilin University, Changchun 130021, China

  • 2.

    School of Life Science, Jilin University, Changchun 130021, China

  • Received Date: 2007-04-09
  • Objective : To determine the dissociation constant and partition coefficient of mesylate delavirdine. Methods :The dissociation constant was determined with acid-base titration method in methanol /water solutions with different ratios,the value to infinite diluted in pure water was extrapolated and the partition coefficient was determined with bottle-shaking method by HPLC. Results : The pKa and 1gP of mesylate delavirdine in n-octyl alcohol were 4.635 and 2.907 respectively. Conclusions : mesylate delavirdine is a weak acid with lipophilic property.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of the dissociation constant and partition coefficient of mesylate delavirdine

  • 1. School of Pharmacy, Jilin University, Changchun 130021, China;School of Life Science, Jilin University, Changchun 130021, China
  • 2. School of Life Science, Jilin University, Changchun 130021, China
  • Received Date: 2007-04-09

Abstract: Objective : To determine the dissociation constant and partition coefficient of mesylate delavirdine. Methods :The dissociation constant was determined with acid-base titration method in methanol /water solutions with different ratios,the value to infinite diluted in pure water was extrapolated and the partition coefficient was determined with bottle-shaking method by HPLC. Results : The pKa and 1gP of mesylate delavirdine in n-octyl alcohol were 4.635 and 2.907 respectively. Conclusions : mesylate delavirdine is a weak acid with lipophilic property.

GUAN Qing-xiang, LIN Tian-mu, WANG En-si. Determination of the dissociation constant and partition coefficient of mesylate delavirdine[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 290-291.
Citation: GUAN Qing-xiang, LIN Tian-mu, WANG En-si. Determination of the dissociation constant and partition coefficient of mesylate delavirdine[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 290-291.
shu

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