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Volume 25 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (2): 94-97

ZHAO Nan, TANG Zhen, WANG Yan-ping, XUE Wan-li. Preparation and study of pharmaceutics of 5-ISMN orally disintegrating tablets[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 94-97.
Citation: ZHAO Nan, TANG Zhen, WANG Yan-ping, XUE Wan-li. Preparation and study of pharmaceutics of 5-ISMN orally disintegrating tablets[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 94-97.
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Preparation and study of pharmaceutics of 5-ISMN orally disintegrating tablets

  • 1.

    The Pharmacy College of Yan Bian University,Yanji 133000,China

  • 2.

    No.208 Hospital of PLA,Changchun,130062,China

  • Received Date: 2006-11-22
  • Objective: To optimize the formulation of 5-ISMN orally disintegrating tablets,and inspect quality of prepared tablets. Methods: The orthogonal design was used and HPLC was used to determine the concentration. Results: Besides 5-ISMN,the tablets were composed of croscarmellose sodium 3%,mannite 15%,lactose 31%,MCC/L-HPC ratio was 8:2(32%,8%).The prepared tablets disintegrated completely in 20s,dissolved more than 80% in 2min and tasty fine. Conclusion: Choose properly excipients,we can produce orally rapidly-disintegrating tablets of rapidly disintegrating,tasty well and rapid absorption.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Preparation and study of pharmaceutics of 5-ISMN orally disintegrating tablets

  • 1. The Pharmacy College of Yan Bian University,Yanji 133000,China
  • 2. No.208 Hospital of PLA,Changchun,130062,China
  • Received Date: 2006-11-22

Abstract: Objective: To optimize the formulation of 5-ISMN orally disintegrating tablets,and inspect quality of prepared tablets. Methods: The orthogonal design was used and HPLC was used to determine the concentration. Results: Besides 5-ISMN,the tablets were composed of croscarmellose sodium 3%,mannite 15%,lactose 31%,MCC/L-HPC ratio was 8:2(32%,8%).The prepared tablets disintegrated completely in 20s,dissolved more than 80% in 2min and tasty fine. Conclusion: Choose properly excipients,we can produce orally rapidly-disintegrating tablets of rapidly disintegrating,tasty well and rapid absorption.

ZHAO Nan, TANG Zhen, WANG Yan-ping, XUE Wan-li. Preparation and study of pharmaceutics of 5-ISMN orally disintegrating tablets[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 94-97.
Citation: ZHAO Nan, TANG Zhen, WANG Yan-ping, XUE Wan-li. Preparation and study of pharmaceutics of 5-ISMN orally disintegrating tablets[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 94-97.
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