Effect of low dose of inhaled corticosteroid combined with asmeton on treatment of bronchial asthma

Key words: 
• corticosteroid /
• asmeton /
• bronchial asthma

Abstract: Objective: To investigate the effect of low dose of inhaled beclomethasone dipropionate(BDP)combined with asmeton on clinical symptoms,bronchial responsiveness and hypothalamic-pituitary-adrenal axis(HPAA). Methods: 96 patients with mild-mod-erate bronchial asthma were randomly divided into CA and C groups.49 subjects in group CA were treated with asmeton(2# tid)and inhaled BDP(300μg/day),47 cases in group C received inhaled BDP(600μg/day), Results: Before and 12 weeks after the treat-ment,symptom scores for group CA were(1.8±0.7)and(0.13±0.16),and those for group C were(1.9±0.9)and(0.13±0.15),which were remarkably improved in both groups(P＜0.01).Frequency of using inhaledβ₂ agonist to relieve nocturnal asthmat-ic attacks in group C(5.9±1.4).was significantly greater than that in group CA(2.3±1.3),(P＜0.05).Plasma ACTH concentra-tions,basic cortisol levels and cortisol responses to ACTH before and 12 weeks after the treatment in group C were(31±11)ng/L and (20±9)ng/L,(97±53)μg/L and(84±43)μg/L,(156±78)% and(75±44)% respectively,which were decreased significant-ly after the treatment(P＜0.05).There were no such changes in group A. Conclusion: It was suggested that asmeton combined with low dose of inhaled BDP might have the same effect on relief of clinical symptoms and bronchial responsiveness,without suppression on HPAA function,comparing with relatively higher dose of inhaled BDP.