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Volume 24 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2006  >  (4): 205-206

JIN Yan, CUI Hui-fei, LING Pei-xue, ZHANG Tian-min. Determination of sulfate groups in polysulfated heparin sodium with conductometry[J]. Journal of Pharmaceutical Practice and Service, 2006, (4): 205-206.
Citation: JIN Yan, CUI Hui-fei, LING Pei-xue, ZHANG Tian-min. Determination of sulfate groups in polysulfated heparin sodium with conductometry[J]. Journal of Pharmaceutical Practice and Service, 2006, (4): 205-206.
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Determination of sulfate groups in polysulfated heparin sodium with conductometry

  • 1.

    School of Pharmacy,Shandong University, Jinan 250012, China;Working Station for Postdoctoral Scientific Research, Institute of Biopharmaceuticals of Shandong Province, Jinan 250108, China

  • 2.

    School of Pharmacy,Shandong University, Jinan 250012, China

  • Received Date: 2006-01-18
  • Objective: To establish a method for the determination of the contents of sulfate groups in polysulfated heparin sodium. Methods: The contents of sulfate groups were determined by converting the Na+ of polysulfated heparin sodium into H+ with cation exchange resin and titrating with sodium hydroxide. The titration end-point was ascertained by variance of conductivity and the results were rectified by cetylpyridinium chloride. Results: The average recovery was 100. 18% ,RSD = 3. 67% . Conclusion: This mthod was simple,reproducible and accurate.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of sulfate groups in polysulfated heparin sodium with conductometry

  • 1. School of Pharmacy,Shandong University, Jinan 250012, China;Working Station for Postdoctoral Scientific Research, Institute of Biopharmaceuticals of Shandong Province, Jinan 250108, China
  • 2. School of Pharmacy,Shandong University, Jinan 250012, China
  • Received Date: 2006-01-18

Abstract: Objective: To establish a method for the determination of the contents of sulfate groups in polysulfated heparin sodium. Methods: The contents of sulfate groups were determined by converting the Na+ of polysulfated heparin sodium into H+ with cation exchange resin and titrating with sodium hydroxide. The titration end-point was ascertained by variance of conductivity and the results were rectified by cetylpyridinium chloride. Results: The average recovery was 100. 18% ,RSD = 3. 67% . Conclusion: This mthod was simple,reproducible and accurate.

JIN Yan, CUI Hui-fei, LING Pei-xue, ZHANG Tian-min. Determination of sulfate groups in polysulfated heparin sodium with conductometry[J]. Journal of Pharmaceutical Practice and Service, 2006, (4): 205-206.
Citation: JIN Yan, CUI Hui-fei, LING Pei-xue, ZHANG Tian-min. Determination of sulfate groups in polysulfated heparin sodium with conductometry[J]. Journal of Pharmaceutical Practice and Service, 2006, (4): 205-206.
shu

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