Research on preparation of aripiprazole

XU Jian-ming; WU Qiu-ye; SUN Qing-yan; ZHANG Jun; YU Shi-chong

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Volume 23 Issue 5

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2005 > (5): 269-270

XU Jian-ming, WU Qiu-ye, SUN Qing-yan, ZHANG Jun, YU Shi-chong. Research on preparation of aripiprazole[J]. Journal of Pharmaceutical Practice and Service, 2005, (5): 269-270.

Citation:

XU Jian-ming, WU Qiu-ye, SUN Qing-yan, ZHANG Jun, YU Shi-chong. Research on preparation of aripiprazole[J]. Journal of Pharmaceutical Practice and Service, 2005, (5): 269-270.

Research on preparation of aripiprazole

School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2005-07-05

Abstract

Objective To optimize the preparation procedure of aripiprazole. Methods 7-hydroxy-3,4-dihydro-2(1H)-quinolin-one was used as starting material and etherified with 1,4-dibromobutane, then alkylated with 1-(2,3-dichlorophenyl) piperazine to yield the target compound aripiprazole. Results The DMF was replaced by acetone as solvent when etherification. The extraction purification method in the last step was replaced by washing precipitates with water. Aripiprazole was prepared in overall yield of 71. 3%. Conclusion The optimal preparation procedure is stable and available for industrial production.
- aripiprazole,
- preparation
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通讯作者: 陈斌, [email protected]

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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