Safety pharmacology study of KNT009

Key words: 
• KNT009 /
• safety pharmacology /
• cardiovascular system /
• respiratory system /
• nervous system

Abstract: Objective To study the effects of KNT009 on nervous, cardiovascular and respiratory system in animals. Methods Mice were randomly divided to receive single 160, 80, 40, and 0 mg/kg dose of KNT009 and 80 mg/kg dose of gatigloxacin respectively and the spontaneous activities and pull-down ability of animals were observed. Dogs were randomly divided to receive single 40, 20, 10 and 0 mg/kg dose of KNT009 and 20 mg/kg dose of gatigloxacin respectively and the blood pressure, ECG, respiratory rate and width of dogs were measured. Results No effects on spontaneous activities and pull-down ability in mice were observed. The systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate and respiratory rate of dogs were decreased, the QT interval was prolonged and the respiratory width was increased in dogs, and there were dose effective relationship, however, these parameters return to normal within 3h. Conclusion KNT009 has some effects on cardiovascular system in dogs such as the blood pressure and heart rate may be decreased and the QT interval may be prolonged, KNT009 also has some effects on respiratory system in dogs such as the respiratory rate may be decreased and the respiratory width may be increased.