Determination of nitrite in gliclazide by HPLC-ECD method

CHEN Long-zhu; XIANG Zhi-min; JIA Fei

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Volume 22 Issue 5

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2004 > (5): 293-294

CHEN Long-zhu, XIANG Zhi-min, JIA Fei. Determination of nitrite in gliclazide by HPLC-ECD method[J]. Journal of Pharmaceutical Practice and Service, 2004, (5): 293-294.

Citation:

CHEN Long-zhu, XIANG Zhi-min, JIA Fei. Determination of nitrite in gliclazide by HPLC-ECD method[J]. Journal of Pharmaceutical Practice and Service, 2004, (5): 293-294.

Determination of nitrite in gliclazide by HPLC-ECD method

Zhejiang Institute for Drug Control, Hangzhou, 310004, China

Received Date: 2003-11-13

Abstract

Objective To establish a HPLC-ECD method for determination of nitrite remaining in gliclazide. Methods A colum of Hypersil-SAX was used. The mobile phase was 13.61g of sodium acetate dissolved in water(pH4.3) with phosphoric acid and diluted to 1000mL. Results The linear range was 0.04～0.80μg(r= 0.9995). The average recovery was 99.2% RSD = 1.7% (n = 9). Conclusion The method was simple and accurate.
- Gliclazide,
- HPLC-ECD,
- nitrite
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通讯作者: 陈斌, [email protected]

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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