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Volume 22 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2004  >  (5): 291-293

JIANG Ye, XU Zhi-ru, TIAN Meng-jun. Determination of the adefovir dipivoxil raw material by nonaqueous acid-base e-lectrolytic titrations[J]. Journal of Pharmaceutical Practice and Service, 2004, (5): 291-293.
Citation: JIANG Ye, XU Zhi-ru, TIAN Meng-jun. Determination of the adefovir dipivoxil raw material by nonaqueous acid-base e-lectrolytic titrations[J]. Journal of Pharmaceutical Practice and Service, 2004, (5): 291-293.
shu

Determination of the adefovir dipivoxil raw material by nonaqueous acid-base e-lectrolytic titrations

  • School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China

  • Received Date: 2003-10-11
  • Objective To establish nonaqueous acicle-base electrolytic titrations method for the determination of adefovir dipivoxil raw material, and investigate the infulents of the proportion of acetic anhydride in the acetric anhydride and anhydro-glacial acetic acid mixed solution. Methods 75% acetric anhydride was selected as the solvent, and 0.1 mol/L perchloric was selected as the standard solution to determine the content of adefovir dipivoxil in raw material. Results It was found that the end point was changed more acuate with the increasing of acetric anhydride proportion in solvent. The average recovery of adefovir dipivoxil raw material was 99.7% and RSD was 0.2%. Conclusion The method was simple, accurate, and is suitable for the quality control of adefovir dipivoxil raw material.
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通讯作者: 陈斌, [email protected]
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Determination of the adefovir dipivoxil raw material by nonaqueous acid-base e-lectrolytic titrations

  • School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
  • Received Date: 2003-10-11

Abstract: Objective To establish nonaqueous acicle-base electrolytic titrations method for the determination of adefovir dipivoxil raw material, and investigate the infulents of the proportion of acetic anhydride in the acetric anhydride and anhydro-glacial acetic acid mixed solution. Methods 75% acetric anhydride was selected as the solvent, and 0.1 mol/L perchloric was selected as the standard solution to determine the content of adefovir dipivoxil in raw material. Results It was found that the end point was changed more acuate with the increasing of acetric anhydride proportion in solvent. The average recovery of adefovir dipivoxil raw material was 99.7% and RSD was 0.2%. Conclusion The method was simple, accurate, and is suitable for the quality control of adefovir dipivoxil raw material.

JIANG Ye, XU Zhi-ru, TIAN Meng-jun. Determination of the adefovir dipivoxil raw material by nonaqueous acid-base e-lectrolytic titrations[J]. Journal of Pharmaceutical Practice and Service, 2004, (5): 291-293.
Citation: JIANG Ye, XU Zhi-ru, TIAN Meng-jun. Determination of the adefovir dipivoxil raw material by nonaqueous acid-base e-lectrolytic titrations[J]. Journal of Pharmaceutical Practice and Service, 2004, (5): 291-293.
shu

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