Effect of astragalus membranaceus injection on congestive heart failure and im- mune regulation

Key words: 
• Astragalus membranaceus /
• heart failure /
• congestive /
• immunity

Abstract: Objective To explore the effect of Astragalus membranaceus injection on congestive heart failure and immune regulation. Methods The serum levers of IgA IgG IgM C3 IL-Ⅱ E-RFC T-LTT and antibody of cardiac muscle were measured in normal control group and CHF group. Then the CHF patients were divided randomly into two groups. Treatment group was infused intravenously daily with Astragalus membranaceus injection added into 5% glucose 250mL for two weeks, which was based on conventional therapy such as digitalis, diuretics and vasodilators. Conventional therapy group was only treated with conventional thearpy. Previous measurements were done again after two weeks. Comparative analysis was made between normal control group and CHF group, and also was made between conventional therapy group and treatment group. Results The level of IL-Ⅱ E-RFC T-LTT antibody of cardiac muscle in the CHF paients were significantly higher then that of normal control group (P<0.01). After two weeks, there was no significant difference in the total effective rate of CHF between two groups (P>0.05), but the obvious effective rate of treatment group was markedly higher than that of conventional therapy group(P >0.05). The decrease of IL-Ⅱ E-RFC T-LTT C3 and antibody of cardiac muscle in treatment group is more obvious than that in conventional therapy group (P<0.01). Conclusion The effect of Astragalus membranaceus injection on cogestive heart failure involves mainly the cell immune and Astragalus membranaceus may have a satisfied cure effect on it.