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Volume 22 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2004  >  (4): 230-232

LI Zhi-mei, LIU Meng, ZHANG Huang-dan. Determination of atropine sulfate eye drops by ion-pair HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (4): 230-232.
Citation: LI Zhi-mei, LIU Meng, ZHANG Huang-dan. Determination of atropine sulfate eye drops by ion-pair HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (4): 230-232.
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Determination of atropine sulfate eye drops by ion-pair HPLC

  • 1.

    Wenzhou Institute of Drug Control, Wenzhou 325028, China

  • 2.

    Wenzhou Development Zone Medicine Co. ltd, Wenzhou 325000, China

  • Received Date: 2004-03-04
  • Objective An ion-pair HPLC method was developed for determination of atropine sulfate in atropine sulfate eye drops. Methods Alltech-C18 (4.6×250mm, 5μm)column was used and the mobile phase was acetonitrile -0.05mol/L sodium hep-tanesul fonate (35:65). It was detected at 210nm. ResultsLinearity was obtained in the concentration rage of 8-120μg/mL, A=-72915.4073 + 15308.1639C,r=0.999. The average recoveries was 100.2%, RSD = 0.65%. Conclusion The method provide a accurate and sensitive way for the determination of atropine sulfate in atropine sulfate eye drops by ion-pair HPLC.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of atropine sulfate eye drops by ion-pair HPLC

  • 1. Wenzhou Institute of Drug Control, Wenzhou 325028, China
  • 2. Wenzhou Development Zone Medicine Co. ltd, Wenzhou 325000, China
  • Received Date: 2004-03-04

Abstract: Objective An ion-pair HPLC method was developed for determination of atropine sulfate in atropine sulfate eye drops. Methods Alltech-C18 (4.6×250mm, 5μm)column was used and the mobile phase was acetonitrile -0.05mol/L sodium hep-tanesul fonate (35:65). It was detected at 210nm. ResultsLinearity was obtained in the concentration rage of 8-120μg/mL, A=-72915.4073 + 15308.1639C,r=0.999. The average recoveries was 100.2%, RSD = 0.65%. Conclusion The method provide a accurate and sensitive way for the determination of atropine sulfate in atropine sulfate eye drops by ion-pair HPLC.

LI Zhi-mei, LIU Meng, ZHANG Huang-dan. Determination of atropine sulfate eye drops by ion-pair HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (4): 230-232.
Citation: LI Zhi-mei, LIU Meng, ZHANG Huang-dan. Determination of atropine sulfate eye drops by ion-pair HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (4): 230-232.
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