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Volume 21 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2003  >  (1): 20-23

YANG Hong-tu, CHANG Cui, NING De-e, XU Qun-ying, BI Dian-zhou. Evaluation of the correlation between in vitro release and in vitro absorption characteristics of nefopam sustained release capsules[J]. Journal of Pharmaceutical Practice and Service, 2003, (1): 20-23.
Citation: YANG Hong-tu, CHANG Cui, NING De-e, XU Qun-ying, BI Dian-zhou. Evaluation of the correlation between in vitro release and in vitro absorption characteristics of nefopam sustained release capsules[J]. Journal of Pharmaceutical Practice and Service, 2003, (1): 20-23.
shu

Evaluation of the correlation between in vitro release and in vitro absorption characteristics of nefopam sustained release capsules

  • 1.

    Department of Pharmacy, The People's Hospital of Shenzhen City, The Second Affiliated Hospital of Jinan University, Shenzhen 518020

  • 2.

    Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110015

  • Received Date: 2002-09-24
  • OBJECTIVE To evaluate the correlativity between in vitro release and in vivo absorption of nefopam sustained release capsules.METHODS The nefopam concentration in human plasma was determined by a high performance liquid chromatography method.According to the Wagner-Nelson formula,the percentage of in vivo absorption of two nefopam sustained release capsules were calculated.In vitro release of nefopam in 3 mediums of different pH was tested and the accumulated release percentage was calculated.RESULTS The variation of pH of mediums were no significant affect on in vitro release rate of nefopam.CONCLUSION A good correlativity was showed between in vivo absorption and in vitro release of nefopam sustained release capsules.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Evaluation of the correlation between in vitro release and in vitro absorption characteristics of nefopam sustained release capsules

  • 1. Department of Pharmacy, The People's Hospital of Shenzhen City, The Second Affiliated Hospital of Jinan University, Shenzhen 518020
  • 2. Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110015
  • Received Date: 2002-09-24

Abstract: OBJECTIVE To evaluate the correlativity between in vitro release and in vivo absorption of nefopam sustained release capsules.METHODS The nefopam concentration in human plasma was determined by a high performance liquid chromatography method.According to the Wagner-Nelson formula,the percentage of in vivo absorption of two nefopam sustained release capsules were calculated.In vitro release of nefopam in 3 mediums of different pH was tested and the accumulated release percentage was calculated.RESULTS The variation of pH of mediums were no significant affect on in vitro release rate of nefopam.CONCLUSION A good correlativity was showed between in vivo absorption and in vitro release of nefopam sustained release capsules.

YANG Hong-tu, CHANG Cui, NING De-e, XU Qun-ying, BI Dian-zhou. Evaluation of the correlation between in vitro release and in vitro absorption characteristics of nefopam sustained release capsules[J]. Journal of Pharmaceutical Practice and Service, 2003, (1): 20-23.
Citation: YANG Hong-tu, CHANG Cui, NING De-e, XU Qun-ying, BI Dian-zhou. Evaluation of the correlation between in vitro release and in vitro absorption characteristics of nefopam sustained release capsules[J]. Journal of Pharmaceutical Practice and Service, 2003, (1): 20-23.
shu

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