Study on the reversing effect of tamoxifen on multidrug resistant cell line K562/DOX

LIANG Yan-chun; WANG Xiu-li

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Volume 19 Issue 5

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2001 > (5): 264-265

LIANG Yan-chun, WANG Xiu-li. Study on the reversing effect of tamoxifen on multidrug resistant cell line K562/DOX[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 264-265.

Citation:

LIANG Yan-chun, WANG Xiu-li. Study on the reversing effect of tamoxifen on multidrug resistant cell line K562/DOX[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 264-265.

Study on the reversing effect of tamoxifen on multidrug resistant cell line K562/DOX

The 150th Hospital of PLA, Luoyang 471031, China

Received Date: 2000-11-20

Abstract

OBJECTIVE To develop effect of tamoxifen on resistance modulators. METHODS The effects of tamoxifen on drug sensitivity in multidrug resistant human leukemic cell line K562/DOX were studied by MTT corlori- metric assay. RESULTS:Tamoxifen enhanced the cytotoxicity of doxorubicin (DOX) to K562/DOX and had no effect on efflux of DOX in K562 cells. CONCLUSION Tamoxifen is an effective reversal agent of multidrug resistance.
- tamoxifen,
- trug tolerance,
- effective reversal agent
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通讯作者: 陈斌, [email protected]

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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