Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 19 Issue 3
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2001  >  (3): 157-159

WEI Hong-chang, WANG Xiu-wei, LU Rong, SHENG Jin-bo, ZHU Xiao-mei, WU Qian, ZHANG Chen. Pharmacological preconditioning of Yixin Oral Liquid (YOL) during myocardium ischemia and reperfusion in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (3): 157-159.
Citation: WEI Hong-chang, WANG Xiu-wei, LU Rong, SHENG Jin-bo, ZHU Xiao-mei, WU Qian, ZHANG Chen. Pharmacological preconditioning of Yixin Oral Liquid (YOL) during myocardium ischemia and reperfusion in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (3): 157-159.
shu

Pharmacological preconditioning of Yixin Oral Liquid (YOL) during myocardium ischemia and reperfusion in rat

  • 1.

    Shanghai TCM University, Shanghai 200032, China

  • 2.

  • 3.

  • Received Date: 2000-12-23
  • OBJECTIVE To investigate the protective mechanism of YOL on ischemia/reperfusion (I/R) myocardium.METHODS48 male SD rats,weighting (260±30)g,were divided into 6 groups.They were normal control,I/R,classical ischemic precondition(C-IPC),sham-operated,Isosorbide dinitrate and YOL.The intracelular calcium concentration of the cardiomyocyte and hemodynamic changes were measured in all groups.RESULTS LVSP、±dp/dt in C-IPC and YOL tread with ischemia 30 min and followed by reperfusion 60 min were obviously higher in I/R(P<0.05)while LVSP、±dp/dt of C-IPC was alsodefinitely high compared with YOL(P<0.05).The intracel ular calcium concentrat ion in C-IPC and YOL were lower in I/R(P<0.05),while[Ca2+]I of YOL was increased in C-IPC (P<0.05).CONCLUSIONS Yix in oral Liquid(YOL)precondit ioning can protect the myocardium from I/R.The possible protective mechanism may be due to decrease calcium overload in cardiomyocyte.
  • 加载中
通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2221) PDF downloads(726) Cited by()

Related
Proportional views

Pharmacological preconditioning of Yixin Oral Liquid (YOL) during myocardium ischemia and reperfusion in rat

  • 1. Shanghai TCM University, Shanghai 200032, China
  • 2. 
  • 3. 
  • Received Date: 2000-12-23

Abstract: OBJECTIVE To investigate the protective mechanism of YOL on ischemia/reperfusion (I/R) myocardium.METHODS48 male SD rats,weighting (260±30)g,were divided into 6 groups.They were normal control,I/R,classical ischemic precondition(C-IPC),sham-operated,Isosorbide dinitrate and YOL.The intracelular calcium concentration of the cardiomyocyte and hemodynamic changes were measured in all groups.RESULTS LVSP、±dp/dt in C-IPC and YOL tread with ischemia 30 min and followed by reperfusion 60 min were obviously higher in I/R(P<0.05)while LVSP、±dp/dt of C-IPC was alsodefinitely high compared with YOL(P<0.05).The intracel ular calcium concentrat ion in C-IPC and YOL were lower in I/R(P<0.05),while[Ca2+]I of YOL was increased in C-IPC (P<0.05).CONCLUSIONS Yix in oral Liquid(YOL)precondit ioning can protect the myocardium from I/R.The possible protective mechanism may be due to decrease calcium overload in cardiomyocyte.

WEI Hong-chang, WANG Xiu-wei, LU Rong, SHENG Jin-bo, ZHU Xiao-mei, WU Qian, ZHANG Chen. Pharmacological preconditioning of Yixin Oral Liquid (YOL) during myocardium ischemia and reperfusion in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (3): 157-159.
Citation: WEI Hong-chang, WANG Xiu-wei, LU Rong, SHENG Jin-bo, ZHU Xiao-mei, WU Qian, ZHANG Chen. Pharmacological preconditioning of Yixin Oral Liquid (YOL) during myocardium ischemia and reperfusion in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (3): 157-159.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: [email protected]

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return