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Volume 19 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2001  >  (2): 78-79

ZHANG Wan-guo, HU Jin-hong, CAI Zhen. Study on hemorheological changes of carbon tetrachloride(CCl4)induced hepatic fibrosis in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (2): 78-79.
Citation: ZHANG Wan-guo, HU Jin-hong, CAI Zhen. Study on hemorheological changes of carbon tetrachloride(CCl4)induced hepatic fibrosis in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (2): 78-79.
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Study on hemorheological changes of carbon tetrachloride(CCl4)induced hepatic fibrosis in rat

  • Department of Pharmacy, Changhai hospital, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2000-09-03
  • OBJECTIVE To study the hemorheological paramenters in rat with hepatic fibrosis. METHODS Hepatic fibrosis in rat was induced by CCl4 treatment. Whole blood viscosity, plasma viscosity, Hematocrit(Hct) and dynamic parameters of red blood cell(RBC) were investigated. RESULTS As compared with the normal group, the hemorheological parameters such as whole blood viscosity, plasma viscosity, Hematocrit(Hct), RBC's aggregation and rigidity were increased obviously. CONCLUSION High blood vicosity and low RBC's deformation ability can lead to blood circulation obstacle, thus will aggravate hepatic fibrosis.
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Study on hemorheological changes of carbon tetrachloride(CCl4)induced hepatic fibrosis in rat

  • Department of Pharmacy, Changhai hospital, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2000-09-03

Abstract: OBJECTIVE To study the hemorheological paramenters in rat with hepatic fibrosis. METHODS Hepatic fibrosis in rat was induced by CCl4 treatment. Whole blood viscosity, plasma viscosity, Hematocrit(Hct) and dynamic parameters of red blood cell(RBC) were investigated. RESULTS As compared with the normal group, the hemorheological parameters such as whole blood viscosity, plasma viscosity, Hematocrit(Hct), RBC's aggregation and rigidity were increased obviously. CONCLUSION High blood vicosity and low RBC's deformation ability can lead to blood circulation obstacle, thus will aggravate hepatic fibrosis.

ZHANG Wan-guo, HU Jin-hong, CAI Zhen. Study on hemorheological changes of carbon tetrachloride(CCl4)induced hepatic fibrosis in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (2): 78-79.
Citation: ZHANG Wan-guo, HU Jin-hong, CAI Zhen. Study on hemorheological changes of carbon tetrachloride(CCl4)induced hepatic fibrosis in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (2): 78-79.
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