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Volume 19 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2001  >  (1): 16-18,64

XIANG Guang-ya, YANG Yu, RUAN Jin-lan, ZHOU Yi-kai. Studies of cytotoxic effect and antitumor effect by Hypericum chinense[J]. Journal of Pharmaceutical Practice and Service, 2001, (1): 16-18,64.
Citation: XIANG Guang-ya, YANG Yu, RUAN Jin-lan, ZHOU Yi-kai. Studies of cytotoxic effect and antitumor effect by Hypericum chinense[J]. Journal of Pharmaceutical Practice and Service, 2001, (1): 16-18,64.
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Studies of cytotoxic effect and antitumor effect by Hypericum chinense

  • 1.

    Invironmental Medical Institute of Tongji Medical College, Huazhong University of Science and Technology, Hubei, Wuhan 430030, China

  • 2.

    Pharmcy College of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

  • Received Date: 2000-06-27
  • OBJECTIVE To study the cytotoxic effect in vitro and antitumor effect in vivo of Hypericum chinense.METHODS MTT and SRB assay method in vitro and antitumor test in vivo were used.RESULTS The extracts F003、F004、F006 and the compounds hyperlacton C, quercetin, quercitrin show cytotoxic effect on different carcinoma cell in vitro; Under the dose of 20.0mg/(kg·d) × 10d, the inhibitory rates of F003、F004、F005 on S180 in mice were 20.7%、12.4%、31.4 %.CONCLUSION Hypericum chinense show cytotoxic effect in vitro and antitumor effect in viva and should he studied further.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Studies of cytotoxic effect and antitumor effect by Hypericum chinense

  • 1. Invironmental Medical Institute of Tongji Medical College, Huazhong University of Science and Technology, Hubei, Wuhan 430030, China
  • 2. Pharmcy College of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • Received Date: 2000-06-27

Abstract: OBJECTIVE To study the cytotoxic effect in vitro and antitumor effect in vivo of Hypericum chinense.METHODS MTT and SRB assay method in vitro and antitumor test in vivo were used.RESULTS The extracts F003、F004、F006 and the compounds hyperlacton C, quercetin, quercitrin show cytotoxic effect on different carcinoma cell in vitro; Under the dose of 20.0mg/(kg·d) × 10d, the inhibitory rates of F003、F004、F005 on S180 in mice were 20.7%、12.4%、31.4 %.CONCLUSION Hypericum chinense show cytotoxic effect in vitro and antitumor effect in viva and should he studied further.

XIANG Guang-ya, YANG Yu, RUAN Jin-lan, ZHOU Yi-kai. Studies of cytotoxic effect and antitumor effect by Hypericum chinense[J]. Journal of Pharmaceutical Practice and Service, 2001, (1): 16-18,64.
Citation: XIANG Guang-ya, YANG Yu, RUAN Jin-lan, ZHOU Yi-kai. Studies of cytotoxic effect and antitumor effect by Hypericum chinense[J]. Journal of Pharmaceutical Practice and Service, 2001, (1): 16-18,64.
shu

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