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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2001  >  (1): 14-16

HU Jia-le, ZHANG Chuan, SU Ding-feng. Attenuates pulmonary dysfunction induced by ischaemia-reperfusion of lower extremitates in rats[J]. Journal of Pharmaceutical Practice and Service, 2001, (1): 14-16.
Citation: HU Jia-le, ZHANG Chuan, SU Ding-feng. Attenuates pulmonary dysfunction induced by ischaemia-reperfusion of lower extremitates in rats[J]. Journal of Pharmaceutical Practice and Service, 2001, (1): 14-16.
shu

Attenuates pulmonary dysfunction induced by ischaemia-reperfusion of lower extremitates in rats

  • 1.

    Division of Hygiene, Logistics Department of 37501 troops, Shanghai 200083, China

  • 2.

    Department of Pharmacology, Department of Basic Medicine, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2000-08-27
  • OBJECTIVE To investigate the therapeutic efficacy of Granulocyte colony-stimulating factor (G-CSF) against rat pulmonary dysfunction induced by ischaemia-reperfusion of lower extremities.METHODS Male Spague-Dawley rats were randomised into three group.The operated and G-CSF group underwent laparotomy and clamping of the infrarenal abdominal aorta for 120min followed by 120min of reperfusion; The sham-operated group underwent laparot-my for 240min only;The G-CSF group was pretreated with G-CSF 20μg/kg through iv and the other given 1ml saline each.A Ⅱ groups reeived Evan's blue dye 30mg/kg iv, preoperatively. Concentrations of lung malonyldiaclehyde (MDA) and Evan's blue blye were measured as marker of lung injury. RESZJLTS Lung MDA level of G-CSF group was(1.71±0.34)nmol/mg;Sham-operated group was(1.73±0.65)nmol/mg,both significantly lower than that of operated group(2.54±0.39)nmol/mg. Even's blue dye concentration was significantly higher in operated group(3.07±1.18)μg/mg than in G-CSF group(1.50±0.29)μg/mg and sham-operated group(0.13±0.07)μg/mg. CONCLUSIGN G-CSF has therapeutic efficacy against pulmonary dysfunction which was induced by ischaemia-reperfusion of lower extremitates in rats.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Attenuates pulmonary dysfunction induced by ischaemia-reperfusion of lower extremitates in rats

  • 1. Division of Hygiene, Logistics Department of 37501 troops, Shanghai 200083, China
  • 2. Department of Pharmacology, Department of Basic Medicine, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2000-08-27

Abstract: OBJECTIVE To investigate the therapeutic efficacy of Granulocyte colony-stimulating factor (G-CSF) against rat pulmonary dysfunction induced by ischaemia-reperfusion of lower extremities.METHODS Male Spague-Dawley rats were randomised into three group.The operated and G-CSF group underwent laparotomy and clamping of the infrarenal abdominal aorta for 120min followed by 120min of reperfusion; The sham-operated group underwent laparot-my for 240min only;The G-CSF group was pretreated with G-CSF 20μg/kg through iv and the other given 1ml saline each.A Ⅱ groups reeived Evan's blue dye 30mg/kg iv, preoperatively. Concentrations of lung malonyldiaclehyde (MDA) and Evan's blue blye were measured as marker of lung injury. RESZJLTS Lung MDA level of G-CSF group was(1.71±0.34)nmol/mg;Sham-operated group was(1.73±0.65)nmol/mg,both significantly lower than that of operated group(2.54±0.39)nmol/mg. Even's blue dye concentration was significantly higher in operated group(3.07±1.18)μg/mg than in G-CSF group(1.50±0.29)μg/mg and sham-operated group(0.13±0.07)μg/mg. CONCLUSIGN G-CSF has therapeutic efficacy against pulmonary dysfunction which was induced by ischaemia-reperfusion of lower extremitates in rats.

HU Jia-le, ZHANG Chuan, SU Ding-feng. Attenuates pulmonary dysfunction induced by ischaemia-reperfusion of lower extremitates in rats[J]. Journal of Pharmaceutical Practice and Service, 2001, (1): 14-16.
Citation: HU Jia-le, ZHANG Chuan, SU Ding-feng. Attenuates pulmonary dysfunction induced by ischaemia-reperfusion of lower extremitates in rats[J]. Journal of Pharmaceutical Practice and Service, 2001, (1): 14-16.
shu

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