Determination of norvancomycin in cerebrospinal fluid by HPLC

XU Jun; WANG-Qinmin

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Volume 18 Issue 6

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2000 > (6): 379-380

XU Jun, WANG-Qinmin. Determination of norvancomycin in cerebrospinal fluid by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 379-380.

Citation:

XU Jun, WANG-Qinmin. Determination of norvancomycin in cerebrospinal fluid by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 379-380.

Determination of norvancomycin in cerebrospinal fluid by HPLC

XU Jun,
WANG-Qinmin

Received Date: 2000-07-20

Abstract

OBJECTIVE To establish a HPLC method for the determination of norvancomycin in cerebrospinal fluid.METHODS With tinidazole as the internal standard, the content of norvancomycin was assayed on a ODS-hypersil C18 column with a mobile phase composed of methanol-phosphate buffer solution(16:84,pH=5.0). The detection wavelength was 280nm.RESULTS Concentration compared with the peak area ratio, the linearity was obtained over the range of 1～60 μg.ml^-1 (r=0.9993).The average recovery was 98.70%±2.65% and the intra-day and the inter-day RSD were within 1.73%～1.95% and 3.62～6.78% respectively.
- norvancomycin,
- cerebrospinal fluid,
- HPLC
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通讯作者: 陈斌, [email protected]

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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