Determination of methadone hydrochloride by HPLC

Lin Cai; Dai Qing; Dong Hui; Ma Wenxiu; Liu Songqing

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Volume 15 Issue 5

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Article Navigation > Journal of Pharmaceutical Practice and Service > 1997 > (5): 299-301

Lin Cai, Dai Qing, Dong Hui, Ma Wenxiu, Liu Songqing. Determination of methadone hydrochloride by HPLC[J]. Journal of Pharmaceutical Practice and Service, 1997, (5): 299-301.

Citation:

Lin Cai, Dai Qing, Dong Hui, Ma Wenxiu, Liu Songqing. Determination of methadone hydrochloride by HPLC[J]. Journal of Pharmaceutical Practice and Service, 1997, (5): 299-301.

Determination of methadone hydrochloride by HPLC

Southwest Hospital, Third Military medical University Chongqing 630038

Abstract

To estab1ish a HPLC method for determining methadone hydrochloride and methadone hydrochloride oral solution.Using a Symmetry-C18 Chlumn,a mixture of acetoni trile-monobasic potassium phosphate(pH2.5)(38:62,V/V)as mobile phase and detected at 220nm bupivacaine hydrochloride was used as internal standard.The average recovery was 100.17%.The RSD for the inter inter and intra-day were all less than 1%.The method is simple,rapid and accurate.
- methadone hydrochloride,
- methadone hydrochloride oral solutinn,
- HPLC
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通讯作者: 陈斌, [email protected]

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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