Effect of naloxone on adenylcyclase activity of canine myocardium

Yang Tiande; Liu Qiaoyi; Wang Zhouqi

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Volume 15 Issue 1

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Article Navigation > Journal of Pharmaceutical Practice and Service > 1997 > (1): 5-7

Yang Tiande, Liu Qiaoyi, Wang Zhouqi. Effect of naloxone on adenylcyclase activity of canine myocardium[J]. Journal of Pharmaceutical Practice and Service, 1997, (1): 5-7.

Citation:

Yang Tiande, Liu Qiaoyi, Wang Zhouqi. Effect of naloxone on adenylcyclase activity of canine myocardium[J]. Journal of Pharmaceutical Practice and Service, 1997, (1): 5-7.

Effect of naloxone on adenylcyclase activity of canine myocardium

Department of Anesthesiology, Xinqiao Hospital, Third Military Medical University Chongqin 630037

Abstract

To elucidate the effect of naloxone on adenylcyclase(AC) of canine myocardium,the adenylcyclase activities of non-ischemic, ischemic and reper fused myocardium were assayed respectively in vivo and in vitro.It was found that intravascular administration of naloxone(1mg.kg^-1) significantly decreased AC activities of ischemic and reper fused myocardium(p<0.01, p<0.05);but naloxone had no effect on AC activities in non-ischemic, ischemic and reperfused myocardium homogenate(p>0.05).It suggested that naloxone have no direct inhibiting effect on activity.
- myocardium,
- naloxone,
- adenylcyclase
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通讯作者: 陈斌, [email protected]

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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