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Volume 13 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 1995  >  (5): 303-305

Wan Xinxiang, Zhang Li, Chen Chucheng, Xia Zhixiang. Determination of nitrofurantoin in urine by second derivative spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 1995, (5): 303-305.
Citation: Wan Xinxiang, Zhang Li, Chen Chucheng, Xia Zhixiang. Determination of nitrofurantoin in urine by second derivative spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 1995, (5): 303-305.
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Determination of nitrofurantoin in urine by second derivative spectrophotometry

  • Guangzhou Medical College of PLA, Guangzhou 510315

  • The paper teported the determination of nitrofuratoin in urine by second derivative spectroscopy. The method consists of direct extraction of the drug by the use of ethyl acetate from the acidic urine and determination of the nitrofurantoin concerntration by measuring the amplitude between the maximum and minimum of the second derivative signal at 374-377nm. The method had a detection limit of 1.5mg/L with recovery of 98% and RSD was less than 3%. The both methods of second derivaive and HPLC had notable relativity.The method could apply to the pharmacokinetics study of nitorfurantoin.
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Determination of nitrofurantoin in urine by second derivative spectrophotometry

  • Guangzhou Medical College of PLA, Guangzhou 510315

Abstract: The paper teported the determination of nitrofuratoin in urine by second derivative spectroscopy. The method consists of direct extraction of the drug by the use of ethyl acetate from the acidic urine and determination of the nitrofurantoin concerntration by measuring the amplitude between the maximum and minimum of the second derivative signal at 374-377nm. The method had a detection limit of 1.5mg/L with recovery of 98% and RSD was less than 3%. The both methods of second derivaive and HPLC had notable relativity.The method could apply to the pharmacokinetics study of nitorfurantoin.

Wan Xinxiang, Zhang Li, Chen Chucheng, Xia Zhixiang. Determination of nitrofurantoin in urine by second derivative spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 1995, (5): 303-305.
Citation: Wan Xinxiang, Zhang Li, Chen Chucheng, Xia Zhixiang. Determination of nitrofurantoin in urine by second derivative spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 1995, (5): 303-305.
shu

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