Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 38 Issue 1
Mar.  2020
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2020  >  38(1): 27-34

PAN Pengchao, CHEN Xiaofei, CHEN Wei, GUO Zhiyong, CHAI Yifeng. Optimization of the compound herba lysimachiae extraction prosess based on orthogonal experiment and response surface method[J]. Journal of Pharmaceutical Practice and Service, 2020, 38(1): 27-34. doi: 10.3969/j.issn.1006-0111.201910001
Citation: PAN Pengchao, CHEN Xiaofei, CHEN Wei, GUO Zhiyong, CHAI Yifeng. Optimization of the compound herba lysimachiae extraction prosess based on orthogonal experiment and response surface method[J]. Journal of Pharmaceutical Practice and Service, 2020, 38(1): 27-34. doi: 10.3969/j.issn.1006-0111.201910001
shu

Optimization of the compound herba lysimachiae extraction prosess based on orthogonal experiment and response surface method

doi: 10.3969/j.issn.1006-0111.201910001
  • 1.

    Department of Pharmaceutical Analysis, School of Pharmacy, Changhai Hospital, Naval Medical University, Shanghai 200433, China

  • 2.

    Department of Nephrology, Changhai Hospital, Naval Medical University, Shanghai 200433, China

  • Received Date: 2019-10-08
  • Rev Recd Date: 2019-12-05
  • Objective To optimize the extraction process of the compound herba lysimachiae by orthogonal experiment and response surface method. Methods The sum of the peak areas of multiple representative components in the compound herba lysimachiae was used as the evaluation index. The ultrasonic extraction time, ultrasonic temperature and ethanol ratio were analyzed to optimize the extraction process conditions by orthogonal experiment and Box-Behnken response surface analysis method. Results Ultrasonic extraction time and ethanol ratio are important factors in the extraction process of the compound herba lysimachiae. The effect of ultrasonic temperature in the extraction process is not significant. The optimal extraction condition for compound herba lysimachiaeare is 10 min ultrasonic extraction time at 55℃ with 55% ethanol. Conclusion The optimal extraction process parameters obtained by combining orthogonal experiment and Box-Behnken response surface method can be used for the extraction of representative components from the compound herba lysimachiae and pharmaceutical research in the future.
  • [1] 甘星, 许远斌, 马治平, 等. 复方金钱草颗粒治疗急性输尿管结石临床研究[J]. 河南中医, 2015, 35(10):2539-2541
    [2] 朱陈辉, 黄海文, 高绍青, 等. 体外冲击波联合复方金钱草颗粒、哈乐在治疗经皮肾镜碎石术后残石的临床疗效分析[J]. 中国医药科学, 2019, 9(2):226-230
    [3] 周军, 韦桂宁, 吴超伟, 等. 复方金钱草颗粒对肾结石的影响及其利尿、解痉、抗炎作用[J]. 中国实验方剂学杂志, 2011, 17(18):206-209
    [4] 崔建敏, 裴保方. 广金钱草多糖的提取工艺及其体外抗氧化活性研究[J]. 新乡医学院学报, 2014, 31(12):986-989
    [5] 刘学, 崔健, 陈新. 广金钱草现代研究进展[J]. 长春中医药大学学报, 2006, 22(4):84-85
    [6] 范文昌, 梅全喜, 赖海标. 广金钱草的药理作用和临床应用研究进展[J]. 中国药房, 2010, 21(31):2961-2963
    [7] 张雪芹, 曲玮, 梁敬钰. 车前草化学成分和药理作用研究进展[J]. 海峡药学, 2013, 25(11):1-8
    [8] 钟鸣, 柴玲. 广金钱草化学成分及药理作用研究进展[J]. 广西医学, 2018, 40(1):80-82
    [9] 李锐. 广金钱草化学成分及分析方法的研究进展[J]. 中国药业, 2009, 18(16):86-87
    [10] MALINI M M, LENIN M, VARALAKSHMI P. Protective effect of triterpenes on calcium oxalate crystal-induced peroxidative changes in experimental urolithiasis[J]. Pharmacol Res,2000,41(4):413-418
    [11] ZHOU J F, JIN J, LI X, et al. Total flavonoids of Desmodium styracifolium attenuates the formation of hydroxy-L-proline-induced calcium oxalate urolithiasis in rats[J]. Urolithiasis,2018,46(3):231-241
    [12] 李惠芝, 庄利民. 广金钱草抑制一水草酸钙结晶生长有效成分的研究[J]. 沈阳药学院学报, 1992, 9(3):194-195
    [13] 杨蓉, 郑虎占. 中药煎煮法的现代研究概况[J]. 中国医药科学, 2012, 2(17):44-46
    [14] 李婷, 陈文学, 田娟娟, 等. 加热回流法提取草果中抗氧化成分的研究[J]. 食品研究与开发, 2009, 30(8):23-26
    [15] 王秋红, 赵珊, 王鹏程, 等. 半仿生提取法在中药提取中的应用[J]. 中国实验方剂学杂志, 2016, 22(18):187-191
    [16] 郭澄, 张纯, 林厚文, 等. 正交试验在中药制剂研究中应用[J]. 时珍国医国药, 2000, 11(4):360-362
  • 加载中
通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(6194) PDF downloads(3152) Cited by()

Related
Proportional views

Optimization of the compound herba lysimachiae extraction prosess based on orthogonal experiment and response surface method

doi: 10.3969/j.issn.1006-0111.201910001
  • 1. Department of Pharmaceutical Analysis, School of Pharmacy, Changhai Hospital, Naval Medical University, Shanghai 200433, China
  • 2. Department of Nephrology, Changhai Hospital, Naval Medical University, Shanghai 200433, China
  • Received Date: 2019-10-08
  • Rev Recd Date: 2019-12-05

Abstract: Objective To optimize the extraction process of the compound herba lysimachiae by orthogonal experiment and response surface method. Methods The sum of the peak areas of multiple representative components in the compound herba lysimachiae was used as the evaluation index. The ultrasonic extraction time, ultrasonic temperature and ethanol ratio were analyzed to optimize the extraction process conditions by orthogonal experiment and Box-Behnken response surface analysis method. Results Ultrasonic extraction time and ethanol ratio are important factors in the extraction process of the compound herba lysimachiae. The effect of ultrasonic temperature in the extraction process is not significant. The optimal extraction condition for compound herba lysimachiaeare is 10 min ultrasonic extraction time at 55℃ with 55% ethanol. Conclusion The optimal extraction process parameters obtained by combining orthogonal experiment and Box-Behnken response surface method can be used for the extraction of representative components from the compound herba lysimachiae and pharmaceutical research in the future.

PAN Pengchao, CHEN Xiaofei, CHEN Wei, GUO Zhiyong, CHAI Yifeng. Optimization of the compound herba lysimachiae extraction prosess based on orthogonal experiment and response surface method[J]. Journal of Pharmaceutical Practice and Service, 2020, 38(1): 27-34. doi: 10.3969/j.issn.1006-0111.201910001
Citation: PAN Pengchao, CHEN Xiaofei, CHEN Wei, GUO Zhiyong, CHAI Yifeng. Optimization of the compound herba lysimachiae extraction prosess based on orthogonal experiment and response surface method[J]. Journal of Pharmaceutical Practice and Service, 2020, 38(1): 27-34. doi: 10.3969/j.issn.1006-0111.201910001
shu

    HTML

Reference (16)

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: [email protected]

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return