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Volume 37 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(6): 521-526

JIA Wei, ZHANG Hongxia, FENG Zhiqiang, SU Lu. Study on preparation and quality of cefotiam hexetil hydrochloride tablet[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 521-526. doi: 10.3969/j.issn.1006-0111.2019.06.010
Citation: JIA Wei, ZHANG Hongxia, FENG Zhiqiang, SU Lu. Study on preparation and quality of cefotiam hexetil hydrochloride tablet[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 521-526. doi: 10.3969/j.issn.1006-0111.2019.06.010
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Study on preparation and quality of cefotiam hexetil hydrochloride tablet

doi: 10.3969/j.issn.1006-0111.2019.06.010
  • 1.

    Xi'an Wanlong Pharmaceutical Co. Ltd, Xi'an 710075, China

  • 2.

    Shaanxi Jiuzhou Pharmaceutical Co. Ltd, Xi'an 710000, China

  • Received Date: 2018-12-03
  • Rev Recd Date: 2019-07-07
  • Objective To study the preparation technology and quality of cefotiam hexetil hydrochloride tablet. Methods The disintegration time limit and dissolution of drug were taken as the main index.The original piece of reference was used to optimize the prescription process and preliminary study on its quality. Results The best prescription was determined by experiments:cefotiam hexetil hydrochloride tablets were prepared by dry granulation with anhydrous citric acid,alpha-cyclodextrin,microcrystalline cellulose,hydroxypropyl cellulose,silica,magnesium stearate and film-coated premix (gastric-soluble).The indexes of cefotiam hexetil hydrochloride tablet conformed to the Japanese Pharmaceutical Bureau Prescription (JPXV) standard. Conclusion The preparation technology of cefotiam hexetil hydrochloride tablet was feasible and the product had good stability.
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    [4] QUEROL-FERRER V,ZINI R,TILLEMENT J P.The blood binding of cefotiam and cyclohexanol,metabolites of the prodrug cefotiam hexetil,in-vitro[J].J Pharm Pharmacol,1991,43(12):863-866.
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    [6] KUCUKBOYACI N E,KEMMOTSU N,CHENG C E,et al.Functional connectivity of the hippocampus in temporal lobe epilepsy:feasibility of a task-regressed seed-based approach[J].Brain Connect,2013,3(5):464-474.
    [7] 韩彬,刘立涛,邵振俊,等.进口头孢替安酯体内外抗菌作用的实验研究[J].四川生理科学杂志,2016,38(2):57-59.
    [8] 杨晨,任凤英,杨红,等.顶空气相色谱法测定盐酸头孢替安酯原料药中残留溶剂含量[J].医药导报,2016,35(2):177-180.
    [9] 任凤英,李强,杨晨,等.RP-HPLC法测定盐酸头孢替安酯的含量及有关物质[J].国外医药(抗生素分册),2012,33(6):253-257.
    [10] WANG D X,LING X,PENG H,et al.High-temperature analogy experimental investigation on dry granulating characteristic of rotating disk for waste heat utilization of molten slag[J].Appl Therm Eng,2017,125(10):846-855.
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    [15] 林集端,赵珺.PEG/α-环糊精准聚轮烷水凝胶与BSA相互作用的光谱学研究[J].化工进展,2016,35(11):3590-3594.
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Study on preparation and quality of cefotiam hexetil hydrochloride tablet

doi: 10.3969/j.issn.1006-0111.2019.06.010
  • 1. Xi'an Wanlong Pharmaceutical Co. Ltd, Xi'an 710075, China
  • 2. Shaanxi Jiuzhou Pharmaceutical Co. Ltd, Xi'an 710000, China
  • Received Date: 2018-12-03
  • Rev Recd Date: 2019-07-07

Abstract: Objective To study the preparation technology and quality of cefotiam hexetil hydrochloride tablet. Methods The disintegration time limit and dissolution of drug were taken as the main index.The original piece of reference was used to optimize the prescription process and preliminary study on its quality. Results The best prescription was determined by experiments:cefotiam hexetil hydrochloride tablets were prepared by dry granulation with anhydrous citric acid,alpha-cyclodextrin,microcrystalline cellulose,hydroxypropyl cellulose,silica,magnesium stearate and film-coated premix (gastric-soluble).The indexes of cefotiam hexetil hydrochloride tablet conformed to the Japanese Pharmaceutical Bureau Prescription (JPXV) standard. Conclusion The preparation technology of cefotiam hexetil hydrochloride tablet was feasible and the product had good stability.

JIA Wei, ZHANG Hongxia, FENG Zhiqiang, SU Lu. Study on preparation and quality of cefotiam hexetil hydrochloride tablet[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 521-526. doi: 10.3969/j.issn.1006-0111.2019.06.010
Citation: JIA Wei, ZHANG Hongxia, FENG Zhiqiang, SU Lu. Study on preparation and quality of cefotiam hexetil hydrochloride tablet[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 521-526. doi: 10.3969/j.issn.1006-0111.2019.06.010
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