HUA Junjie, ZHU Haifei, LI Yu. Determination of sodium fluoride in fluoride-containing mouthwash by 19F-NMR[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 518-520. doi: 10.3969/j.issn.1006-0111.2019.06.009
| Citation:
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HUA Junjie, ZHU Haifei, LI Yu. Determination of sodium fluoride in fluoride-containing mouthwash by 19F-NMR[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 518-520. doi: 10.3969/j.issn.1006-0111.2019.06.009
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Determination of sodium fluoride in fluoride-containing mouthwash by 19F-NMR
- Received Date: 2019-04-12
- Rev Recd Date:
2019-07-20
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Abstract
Objective To establish a method for the determination of sodium fluoride in fluoride-containing mouthwash by 19F-NMR technique. Methods The 19F-NMR technique was used to establish the relevant standard curve with trifluoroacetic acid as the internal standard.The 19F-NMR spectrum of the sample was collected at 25℃ using a 300 MHz NMR spectrometer. Results The linear relationship of sodium fluoride was good in the range of 0.1-0.8 mg/ml.The regression equation was A=1.1392C-0.0013,r=0.99995.The average recovery of low,medium and high concentration levels were 99.36%,99.31.% and 99.65%,respectively,and RSD was 0.51%,0.35% and 0.54% respectively.The average content of sodium fluoride in the fluoride mouthwash was 99.30%. Conclusion The method was accurate and precise which could be used to determine the sodium fluoride in fluoride-containing mouthwash.
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