Efficacy and safety of fluticasone furoate/vilanterol in patients with asthma: a systematic review by Meta-analysis

LIN Lili; YAO Nannan; WU Jue; LIU Zhihong; SONG Hongtao

doi:10.3969/j.issn.1006-0111.2019.05.018

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2019 > 37(5): 473-480

LIN Lili, YAO Nannan, WU Jue, LIU Zhihong, SONG Hongtao. Efficacy and safety of fluticasone furoate/vilanterol in patients with asthma: a systematic review by Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 473-480. doi: 10.3969/j.issn.1006-0111.2019.05.018

Citation:

LIN Lili, YAO Nannan, WU Jue, LIU Zhihong, SONG Hongtao. Efficacy and safety of fluticasone furoate/vilanterol in patients with asthma: a systematic review by Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 473-480. doi: 10.3969/j.issn.1006-0111.2019.05.018

Efficacy and safety of fluticasone furoate/vilanterol in patients with asthma: a systematic review by Meta-analysis

doi: 10.3969/j.issn.1006-0111.2019.05.018

1.
Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
2.
Department of Pharmacy, No. 900 Hospital of Joint Service Support Force, Fuzhou 350025, China

Received Date: 2018-10-10
Rev Recd Date: 2018-12-29

Abstract

Objective To evaluate the efficacy and safety of once-daily fluticasone furoate/vilanterol compared with ICS alone or twice-daily ICS/LABA formulations in patients with asthma. Methods Systematic search was performed for randomized controlled trials in the CNKI,PubMed,Embase and Cochrane Library. Results 10 citations contained 9 811 patients with asthma met the selection criteria. In terms of efficacy,compared with the control group,the patient's trough forced expiratory volume in one second[WMD=0.09,95% Cl(0.05,0.13) P=0.000] and asthma control Test score[WMD=0.63,95% CI(0.24,1.03),P=0.002] were increased in the FF/VI group. In terms of safety,the risk of adverse reaction events associated with treatment in patients was not increased in the FF/VI group compared to the control group[RR=1.15,95% CI(0.98,1.36),P=0.000]. Conclusion FF/VI had advantages and better tolerance in treating asthma patients. It is recommended to be used for its once-daily use of the frequency,which was the advantage of improving patient adherence.
- fluticasone furoate,
- vilanterol,
- ICS,
- LABA,
- asthma,
- Meta-analysis

References

[1]	林燕萍.支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗和管理方案)[C].中国中西医结合变态反应学术会议.2009.
[2]	BATEMAN E D,HURD S S,BARNES P J,et al. Global strategy for asthma management and prevention:GINA executive summary[J].Eur Respir J,2008,31(1):143-178.
[3]	BLAIS L,SUISSA S,BOIVIN J F,et al. First treatment with inhaled corticosteroids and the prevention of admissions to hospital for asthma[J].Thorax,1998,53(12):1025-1029.
[4]	SHIMODA T,OBASE Y,KISHIKAWA R,et al. Impact of inhaled corticosteroid treatment on 15-year longitudinal respiratory function changes in adult patients with bronchial asthma[J].Int Arch Allergy Immunol,2013,162(4):323-329.
[5]	SUISSA S,ERNST P,BENAYOUN S,et al. Low-dose inhaled corticosteroids and the prevention of death from asthma[J].N Engl J Med,2000,343(5):332-336.
[6]	TOY E L,BEAULIEU N U,MCHALE J M,et al. Treatment of COPD:Relationships between daily dosing frequency,adherence,resource use,and costs[J].Respir Med,2011,105(3):435-441.
[7]	GAMBLE J,STEVENSON M,MCCLEAN E,et al. The prevalence of nonadherence in difficult asthma[J]. Am J Respir Crit Care Med,2009,180(9):817-822.
[8]	BERNSTEIN D I,BATEMAN E D,WOODCOCK A,et al. Fluticasone furoate (FF)/vilanterol (100/25mcg or 200/25mcg) or FF (100mcg) in persistent asthma[J]. J Asthma,2015,52(10):1073-1083.
[9]	DEVILLIER P,HUMBERT M,BOYE A,et al. Efficacy and safety of once-daily fluticasone furoate/vilanterol (FF/VI) versus twice-daily inhaled corticosteroids/long-acting β₂-agonists (ICS/LABA) in patients with uncontrolled asthma:An open-label,randomized,controlled trial[J].Respir Med,2018,141:111-120.
[10]	JACQUES L,BAKERLY N D,NEW J P,et al. Effectiveness of fluticasone furoate/vilanterol versus fluticasone propionate/salmeterol on asthma control in the Salford Lung Study[J].J Asthma,2018:1-10.
[11]	张菲,江兵,缪李丽.糠酸氟替卡松治疗支气管哮喘疗效及安全性的系统评价[J].中国循证医学杂志,2017,17(1):33-39.
[12]	MOHER D,LIBERATI A,TETZLAFF J,et al. Preferred reporting items for systematic reviews and meta-analyses:The PRISMA statement[J].Int J Surg,2010,8(5):336-341.
[13]	BUSSE W W,O'BYRNE P M,BLEECKER E R,et al. Safety and tolerability of the novel inhaled corticosteroid fluticasone furoate in combination with the β₂-agonist vilanterol administered once daily for 52 weeks in patients ≥ 12 years old with asthma:a randomised trial[J].Thorax,2013,68(6):513-520.
[14]	WOODCOCK A,BLEECKER E R,LOTVALL J,et al. Efficacy and safety of fluticasone furoate/vilanterol compared with fluticasone propionate/salmeterol combination in adult and adolescent patients with persistent asthma:a randomized trial[J].Chest,2013,144(4):1222-1229.
[15]	O'BYRNE P M,BLEECKER E R,BATEMAN E D,et al. Once-daily fluticasone furoate alone or combined with vilanterol in persistent asthma[J].Eur Respir J,2014,43(3):773-782.
[16]	BATEMAN E D,O'BYRNE P M,BUSSE W W,et al. Once-daily fluticasone furoate (FF)/vilanterol reduces risk of severe exacerbations in asthma versus FF alone[J].Thorax,2014,69(4):312-319.
[17]	BLEECKER E R,LOTVALL J,O'BYRNE P M,et al. Fluticasone furoate-vilanterol 100-25 mcg compared with fluticasone furoate 100 mcg in asthma:a randomized trial[J].J Allergy Clin Immunol Pract,2014,2(5):553-561.
[18]	LIN J,KANG J,LEE S H,et al. Fluticasone furoate/vilanterol 200/25 mcg in Asian asthma patients:A randomized trial[J].Respir Med,2015,109(1):44-53.
[19]	BERNSTEIN D I,BATEMAN E D,WOODCOCK A,et al. Fluticasone furoate (FF)/vilanterol (100/25mcg or 200/25mcg) or FF (100mcg) in persistent asthma[J]. J Asthma,2015,52(10):1073-1083.
[20]	GROSS A S,GOLDFRAD C,HOZAWA S,et al. Ethnic sensitivity assessment of fluticasone furoate/vilanterol in East Asian asthma patients from randomized double-blind multicentre Phase Ⅱb/Ⅲ trials[J]. Bmc Pulm Med,2015,15(1).
[21]	DEVILLIER P,HUMBERT M,BOYE A,et al. Efficacy and safety of once-daily fluticasone furoate/vilanterol (FF/VI) versus twice-daily inhaled corticosteroids/long-acting β₂-agonists (ICS/LABA) in patients with uncontrolled asthma:An open-label,randomized,controlled trial[J].Respir Med,2018,141:111-120.
[22]	BIGGADIKE K. Fluticasone furoate/fluticasone propionate-different drugs with different properties[J].Clin Respir J,2011,5(3):183-184.
[23]	BIGGADIKE K,BLEDSOE R K,HASSELL A M,et al. X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocoricoid receptor ligand binding domain[J].J Med Chem,2008,51(12):3349-3352.
[24]	SALTER M,BIGGADIKE K,MATTHEWS J L,et al. Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease[J].Am J Physiol-Lung C,2007,293(3):L660-L667.
[25]	VALOTIS A,HOGGER P. Human receptor kinetics and lung tissue retention of the enhanced-affinity glucocorticoid fluticasone furoate[J].Respir Res,2007,8:54.
[26]	ALLEN A,BAREILLE P J,ROUSELL V M. Fluticasone furoate,a novel inhaled corticosteroid,demonstrates prolonged lung absorption kinetics in man compared with inhaled fluticasone propionate[J].Clin Pharmacokinet,2013,52(1):37-42.
[27]	ROSSIOS C,TO Y,TO M,et al. Long-acting fluticasone furoate has a superior pharmacological profile to fluticasone propionate in human respiratory cells[J].Eur J Pharmacol,2011,670(1):244-251.
[28]	PROCOPIOU P A,BARRETT V J,BEVAN N J,et al. Synthesis and structure activity relationships of long-acting β₂ adrenergic receptor agonists incorporating metabolic inactivation:an antedrug approach[J].J Med Chem,2010,53(11):4522-4530.

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通讯作者: 陈斌, [email protected]

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Efficacy and safety of fluticasone furoate/vilanterol in patients with asthma: a systematic review by Meta-analysis

1. Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

2. Department of Pharmacy, No. 900 Hospital of Joint Service Support Force, Fuzhou 350025, China

Received Date: 2018-10-10

Rev Recd Date: 2018-12-29

Key words:

Abstract: Objective To evaluate the efficacy and safety of once-daily fluticasone furoate/vilanterol compared with ICS alone or twice-daily ICS/LABA formulations in patients with asthma. Methods Systematic search was performed for randomized controlled trials in the CNKI,PubMed,Embase and Cochrane Library. Results 10 citations contained 9 811 patients with asthma met the selection criteria. In terms of efficacy,compared with the control group,the patient's trough forced expiratory volume in one second[WMD=0.09,95% Cl(0.05,0.13) P=0.000] and asthma control Test score[WMD=0.63,95% CI(0.24,1.03),P=0.002] were increased in the FF/VI group. In terms of safety,the risk of adverse reaction events associated with treatment in patients was not increased in the FF/VI group compared to the control group[RR=1.15,95% CI(0.98,1.36),P=0.000]. Conclusion FF/VI had advantages and better tolerance in treating asthma patients. It is recommended to be used for its once-daily use of the frequency,which was the advantage of improving patient adherence.

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Reference (28)

[1]	林燕萍.支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗和管理方案)[C].中国中西医结合变态反应学术会议.2009.
[2]	BATEMAN E D,HURD S S,BARNES P J,et al. Global strategy for asthma management and prevention:GINA executive summary[J].Eur Respir J,2008,31(1):143-178.
[3]	BLAIS L,SUISSA S,BOIVIN J F,et al. First treatment with inhaled corticosteroids and the prevention of admissions to hospital for asthma[J].Thorax,1998,53(12):1025-1029.
[4]	SHIMODA T,OBASE Y,KISHIKAWA R,et al. Impact of inhaled corticosteroid treatment on 15-year longitudinal respiratory function changes in adult patients with bronchial asthma[J].Int Arch Allergy Immunol,2013,162(4):323-329.
[5]	SUISSA S,ERNST P,BENAYOUN S,et al. Low-dose inhaled corticosteroids and the prevention of death from asthma[J].N Engl J Med,2000,343(5):332-336.
[6]	TOY E L,BEAULIEU N U,MCHALE J M,et al. Treatment of COPD:Relationships between daily dosing frequency,adherence,resource use,and costs[J].Respir Med,2011,105(3):435-441.
[7]	GAMBLE J,STEVENSON M,MCCLEAN E,et al. The prevalence of nonadherence in difficult asthma[J]. Am J Respir Crit Care Med,2009,180(9):817-822.
[8]	BERNSTEIN D I,BATEMAN E D,WOODCOCK A,et al. Fluticasone furoate (FF)/vilanterol (100/25mcg or 200/25mcg) or FF (100mcg) in persistent asthma[J]. J Asthma,2015,52(10):1073-1083.
[9]	DEVILLIER P,HUMBERT M,BOYE A,et al. Efficacy and safety of once-daily fluticasone furoate/vilanterol (FF/VI) versus twice-daily inhaled corticosteroids/long-acting β₂-agonists (ICS/LABA) in patients with uncontrolled asthma:An open-label,randomized,controlled trial[J].Respir Med,2018,141:111-120.
[10]	JACQUES L,BAKERLY N D,NEW J P,et al. Effectiveness of fluticasone furoate/vilanterol versus fluticasone propionate/salmeterol on asthma control in the Salford Lung Study[J].J Asthma,2018:1-10.
[11]	张菲,江兵,缪李丽.糠酸氟替卡松治疗支气管哮喘疗效及安全性的系统评价[J].中国循证医学杂志,2017,17(1):33-39.
[12]	MOHER D,LIBERATI A,TETZLAFF J,et al. Preferred reporting items for systematic reviews and meta-analyses:The PRISMA statement[J].Int J Surg,2010,8(5):336-341.
[13]	BUSSE W W,O'BYRNE P M,BLEECKER E R,et al. Safety and tolerability of the novel inhaled corticosteroid fluticasone furoate in combination with the β₂-agonist vilanterol administered once daily for 52 weeks in patients ≥ 12 years old with asthma:a randomised trial[J].Thorax,2013,68(6):513-520.
[14]	WOODCOCK A,BLEECKER E R,LOTVALL J,et al. Efficacy and safety of fluticasone furoate/vilanterol compared with fluticasone propionate/salmeterol combination in adult and adolescent patients with persistent asthma:a randomized trial[J].Chest,2013,144(4):1222-1229.
[15]	O'BYRNE P M,BLEECKER E R,BATEMAN E D,et al. Once-daily fluticasone furoate alone or combined with vilanterol in persistent asthma[J].Eur Respir J,2014,43(3):773-782.
[16]	BATEMAN E D,O'BYRNE P M,BUSSE W W,et al. Once-daily fluticasone furoate (FF)/vilanterol reduces risk of severe exacerbations in asthma versus FF alone[J].Thorax,2014,69(4):312-319.
[17]	BLEECKER E R,LOTVALL J,O'BYRNE P M,et al. Fluticasone furoate-vilanterol 100-25 mcg compared with fluticasone furoate 100 mcg in asthma:a randomized trial[J].J Allergy Clin Immunol Pract,2014,2(5):553-561.
[18]	LIN J,KANG J,LEE S H,et al. Fluticasone furoate/vilanterol 200/25 mcg in Asian asthma patients:A randomized trial[J].Respir Med,2015,109(1):44-53.
[19]	BERNSTEIN D I,BATEMAN E D,WOODCOCK A,et al. Fluticasone furoate (FF)/vilanterol (100/25mcg or 200/25mcg) or FF (100mcg) in persistent asthma[J]. J Asthma,2015,52(10):1073-1083.
[20]	GROSS A S,GOLDFRAD C,HOZAWA S,et al. Ethnic sensitivity assessment of fluticasone furoate/vilanterol in East Asian asthma patients from randomized double-blind multicentre Phase Ⅱb/Ⅲ trials[J]. Bmc Pulm Med,2015,15(1).
[21]	DEVILLIER P,HUMBERT M,BOYE A,et al. Efficacy and safety of once-daily fluticasone furoate/vilanterol (FF/VI) versus twice-daily inhaled corticosteroids/long-acting β₂-agonists (ICS/LABA) in patients with uncontrolled asthma:An open-label,randomized,controlled trial[J].Respir Med,2018,141:111-120.
[22]	BIGGADIKE K. Fluticasone furoate/fluticasone propionate-different drugs with different properties[J].Clin Respir J,2011,5(3):183-184.
[23]	BIGGADIKE K,BLEDSOE R K,HASSELL A M,et al. X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocoricoid receptor ligand binding domain[J].J Med Chem,2008,51(12):3349-3352.
[24]	SALTER M,BIGGADIKE K,MATTHEWS J L,et al. Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease[J].Am J Physiol-Lung C,2007,293(3):L660-L667.
[25]	VALOTIS A,HOGGER P. Human receptor kinetics and lung tissue retention of the enhanced-affinity glucocorticoid fluticasone furoate[J].Respir Res,2007,8:54.
[26]	ALLEN A,BAREILLE P J,ROUSELL V M. Fluticasone furoate,a novel inhaled corticosteroid,demonstrates prolonged lung absorption kinetics in man compared with inhaled fluticasone propionate[J].Clin Pharmacokinet,2013,52(1):37-42.
[27]	ROSSIOS C,TO Y,TO M,et al. Long-acting fluticasone furoate has a superior pharmacological profile to fluticasone propionate in human respiratory cells[J].Eur J Pharmacol,2011,670(1):244-251.
[28]	PROCOPIOU P A,BARRETT V J,BEVAN N J,et al. Synthesis and structure activity relationships of long-acting β₂ adrenergic receptor agonists incorporating metabolic inactivation:an antedrug approach[J].J Med Chem,2010,53(11):4522-4530.

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Efficacy and safety of fluticasone furoate/vilanterol in patients with asthma: a systematic review by Meta-analysis

doi: 10.3969/j.issn.1006-0111.2019.05.018

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通讯作者: 陈斌, [email protected]

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