Research progress of metabolomics in leukemia

SONG Zhiqiang; ZHU Zhenyu; LIU Yue; CHAI Yifeng

doi:10.3969/j.issn.1006-0111.2019.05.001

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2019 > 37(5): 385-389,399

SONG Zhiqiang, ZHU Zhenyu, LIU Yue, CHAI Yifeng. Research progress of metabolomics in leukemia[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 385-389,399. doi: 10.3969/j.issn.1006-0111.2019.05.001

Citation:

SONG Zhiqiang, ZHU Zhenyu, LIU Yue, CHAI Yifeng. Research progress of metabolomics in leukemia[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 385-389,399. doi: 10.3969/j.issn.1006-0111.2019.05.001

Research progress of metabolomics in leukemia

doi: 10.3969/j.issn.1006-0111.2019.05.001

School of Pharmacy, Naval Medical University, Shanghai 200433, China

Received Date: 2019-01-12
Rev Recd Date: 2019-06-21

Abstract

Metabolomics is a new science to quantitatively or qualitatively analyze all the endogenous small molecule metabolites in biological system(cells,tissues,organs,living organisms),which reveals the metabolic nature of diseases by studying the laws between changes in metabolites and metabolic pathways and physiological and pathological changes.Leukemia is a common malignant tumor of the blood system,which occurrence and development are closely related to metabolism.Endogenous small molecule metabolites discovered by metabolomics had been widely used in the study of pathogenesis,diagnosis and pharmacodynamic mechanism of leukemia and made significant progress.The advances of metabolomics about the study of pathogenesis,diagnosis and pharmacodynamic mechanism of leukemia in recent years were reviewed in this paper in order to provide reference for further research.
- metabolomics,
- leukemia,
- endogenous small molecule metabolites,
- pathogenesis,
- diagnosis,
- pharmacodynamic mechanism

References

[1]	徐超,任立红.代谢组学在白血病中的应用[J].医学综述,2018,24(7):1294-1298.
[2]	AMITAY E L,KEINAN-BOKER L.Breastfeeding and childhood leukemia incidence:a meta-analysis and systematic review[J].JAMA Pediatr,2015,169(6):e151025.
[3]	ONCIU M.Acute lymphoblastic leukemia[J].Hematol Oncol Clin North Am,2009,23(4):655-674.
[4]	HANAHAN D,WEINBERG R A.Hallmarks of cancer:the next generation[J].Cell,2011,144(5):646-674.
[5]	TAI E W,WARD K C,BONAVENTURE A,et al.Survival among children diagnosed with acute lymphoblastic leukemia in the United States,by race and age,2001 to 2009:Findings from the CONCORD-2 study[J].Cancer,2017,123(Suppl 24):5178-5189.
[6]	JEMAL A,SIEGEL R,XU J,et al.Cancer statistics,2010[J].CA Cancer J Clin,2010,60(5):277-300.
[7]	DIAMANTI P,COX C V,MOPPETT J P,et al.Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemia[J].Blood,2013,121(8):1384-1393.
[8]	PELKONEN O,TERRON A,HERNANDEZ A F,et al.Chemical exposure and infant leukaemia:development of an adverse outcome pathway (AOP) for aetiology and risk assessment research[J].Arch Toxicol,2017,91(8):2763-2780.
[9]	MARCOTTE E L,THOMOPOULOS T P,INFANTE——RIVARD C,et al.Caesarean delivery and risk of childhood leukaemia:a pooled analysis from the Childhood Leukemia International Consortium (CLIC)[J].Lancet Haematol,2016,3(4):e176-e185.
[10]	ZHANG M Y,LIU Y,LIU M,et al.UHPLC-QTOF/MS-based metabolomics investigation for the protective mechanism of Danshen in Alzheimer's disease cell model induced by Aβ_1-42[J].Metabolomics,2019,15(2):13.
[11]	ZHANG H,ZHAO Y H,XIA Z X,et al.Metabolic profiles revealed anti-ischemia-reperfusion injury of Yangxinshi tablet in Rats[J].J Ethnopharmacol,2018,214:124-133.
[12]	ARMITAGE E G,SOUTHAM A D.Monitoring cancer prognosis,diagnosis and treatment efficacy using metabolomics and lipidomics[J].Metabolomics,2016,12:146.
[13]	DUARTE I F,DIAZ S O,GIL A M.NMR metabolomics of human blood and urine in disease research[J].J Pharm Biomed Anal,2014,93:17-26.
[14]	刘悦,赵亮,李燕,等.肝细胞性肝癌代谢组学研究进展[J].药学实践杂志,2013,31(2):81-85.
[15]	IBARRA-GONZÁLEZ I,CRUZ-BAUTISTA I,BELLO-CHAVOLLA O Y,et al.Optimization of kidney dysfunction prediction in diabetic kidney disease using targeted metabolomics[J].Acta Diabetol,2018,55(11):1151-1161.
[16]	LE Y C,SHEN X Y,KANG H Y,et al.Accelerated,untargeted metabolomics analysis of cutaneous T-cell lymphoma reveals metabolic shifts in plasma and tumor adjacent skins of xenograft mice[J].J Mass Spectrom,2018,53(8):739.
[17]	XU J,LI J S,ZHANG R P,et al.Development of a metabolic pathway-based pseudo-targeted metabolomics method using liquid chromatography coupled with mass spectrometry[J].Talanta,2019,192:160-168.
[18]	AMBERG A,RIEFKE B,SCHLOTTERBECK G,et al.NMR and MSmethods for metabolomics[J].Methods Mol Biol,2017,1641:229-258.
[19]	PAPADIMITROPOULOS M P,VASILOPOULOU C G,MAGA-NTEVE C,et al.Untargeted GC-MS metabolomics[J].Methods Mol Biol,2018,1738:133-147.
[20]	LIU W J,SONG Q Q,CAO Y,et al.From ¹H NMR-based non-targeted to LC-MS-based targeted metabolomics strategy for in-depth chemome comparisons among four Cistanche species[J].J Pharm Biomed Anal,2019,162:16-27.
[21]	RAMAUTAR R,SOMSEN G W,DE JONG G J.CE-MS for metabolomics:Developments and applications in the period 2014-2016[J].Electrophoresis,2017,38(1):190-202.
[22]	YAN M,XU G W.Current and future perspectives of functional metabolomics in disease studies-A review[J].Anal Chim Acta,2018,1037:41-54.
[23]	LIU Y,LU S,ZHAO L,et al.Effects of glaucocalyxin A on human liver cancer cells as revealed by GC/MS- and LC/MS-based metabolic profiling[J].Anal Bioanal Chem,2018,410(14):3325-3335.
[24]	WU Q,ZHANG H,DING J R,et al.UPLC-QTOF MS——based serum metabolomic profiling analysis reveals the molecular perturbations underlying uremic pruritus[J].Biomed Res Int,2018,2018:4351674.
[25]	MAYER R L,SCHWARZMEIER J D,GERNER M C,et al.Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia[J].Mol Cell Proteomics,2018,17(2):290-303.
[26]	ALTMAN B J,STINE Z E,DANG C V.From Krebs to clinic:glutamine metabolism to cancer therapy[J].Nat Rev Cancer,2016,16(11):749.
[27]	AGATHOCLEOUS M,MEACHAM C E,BURGESS R J,et al.Ascorbate regulates haematopoietic stem cell function and leukaemogenesis[J].Nature,2017,549(7673):476-481.
[28]	OTTO A M.Warburg effect(s)-a biographical sketch of Otto Warburg and his impacts on tumor metabolism[J].Cancer Metab,2016,4:5.
[29]	VANDER HEIDEN M G,CANTLEY L C,THOMPSON C B.Understanding the Warburg effect:the metabolic requirements of cell proliferation[J].Science,2009,324(5930):1029-1033.
[30]	MUSHARRAF S G,SIDDIQUI A J,SHAMSI T,et al.SERUM metabolomics of acute lymphoblastic leukaemia and acute myeloid leukaemia for probing biomarker molecules[J].Hematol Oncol,2017,35(4):769-777.
[31]	GUO D M,LIU Q Q,LI B B,et al.Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21:A case report[J].Oncol Lett,2014,7(2):565-567.
[32]	YANG B Y,LI X L,YAO Y,et al.Metabolomics ofchronic myelogenous leukemia based on GC-MS[J].Zhongguo Shi Yan Xue Ye Xue Za Zhi,2017,25(6):1585-1591.
[33]	CHEN W L,WANG J H,ZHAO A H,et al.A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value[J].Blood,2014,124(10):1645-1654.
[34]	WANG Y H,ZHANG L M,CHEN W L,et al.Rapid diagnosis and prognosis of de novo acute myeloid leukemia by serum metabonomic analysis[J].J Proteome Res,2013,12(10):4393-4401.
[35]	ZHANG X L,YANG J,CHEN M J,et al.Metabolomics profiles delineate uridine deficiency contributes to mitochondria-mediated apoptosis induced by celastrol in human acute promyelocytic leukemia cells[J].Oncotarget,2016,7(29):46557-46572.
[36]	PERNICOVA I,KORBONITS M.Metformin:mode of action and clinical implications for diabetes and cancer[J].Nat Rev Endocrinol,2014,10(3):143-156.
[37]	MILLER R A,BIRNBAUM M J.An energetic tale of AMPK-independent effects of metformin[J].J Clin Invest,2010,120(7):2267-2270.
[38]	SCOTLAND S,SALAND E,SKULI N,et al.Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells[J].Leukemia,2013,27(11):2129-2138.
[39]	KOOPAL C,MARAIS A D,WESTERINK J,et al.Effect of adding bezafibrate to standard lipid-lowering therapy on post-fat load lipid levels in patients with familial dysbetalipoproteinemia.A randomized placebo-controlled crossover trial[J].J Lipid Res,2017,58(11):2180-2187.
[40]	SOUTHAM A D,KHANIM F L,HAYDEN R E,et al.Drugredeployment to kill leukemia and lymphoma cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids[J].Cancer Res,2015,75(12):2530-2540.
[41]	STÄUBERT C,BHUIYAN H,LINDAHL A,et al.Rewired metabolism in drug-resistant leukemia cells:a metabolic switch hallmarked by reduced dependence on exogenous glutamine[J].J Biol Chem,2015,290(13):8348-8359.

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通讯作者: 陈斌, [email protected]

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沈阳化工大学材料科学与工程学院沈阳 110142

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Research progress of metabolomics in leukemia

School of Pharmacy, Naval Medical University, Shanghai 200433, China

Received Date: 2019-01-12

Rev Recd Date: 2019-06-21

Key words:

Abstract: Metabolomics is a new science to quantitatively or qualitatively analyze all the endogenous small molecule metabolites in biological system(cells,tissues,organs,living organisms),which reveals the metabolic nature of diseases by studying the laws between changes in metabolites and metabolic pathways and physiological and pathological changes.Leukemia is a common malignant tumor of the blood system,which occurrence and development are closely related to metabolism.Endogenous small molecule metabolites discovered by metabolomics had been widely used in the study of pathogenesis,diagnosis and pharmacodynamic mechanism of leukemia and made significant progress.The advances of metabolomics about the study of pathogenesis,diagnosis and pharmacodynamic mechanism of leukemia in recent years were reviewed in this paper in order to provide reference for further research.

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Reference (41)

[1]	徐超,任立红.代谢组学在白血病中的应用[J].医学综述,2018,24(7):1294-1298.
[2]	AMITAY E L,KEINAN-BOKER L.Breastfeeding and childhood leukemia incidence:a meta-analysis and systematic review[J].JAMA Pediatr,2015,169(6):e151025.
[3]	ONCIU M.Acute lymphoblastic leukemia[J].Hematol Oncol Clin North Am,2009,23(4):655-674.
[4]	HANAHAN D,WEINBERG R A.Hallmarks of cancer:the next generation[J].Cell,2011,144(5):646-674.
[5]	TAI E W,WARD K C,BONAVENTURE A,et al.Survival among children diagnosed with acute lymphoblastic leukemia in the United States,by race and age,2001 to 2009:Findings from the CONCORD-2 study[J].Cancer,2017,123(Suppl 24):5178-5189.
[6]	JEMAL A,SIEGEL R,XU J,et al.Cancer statistics,2010[J].CA Cancer J Clin,2010,60(5):277-300.
[7]	DIAMANTI P,COX C V,MOPPETT J P,et al.Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemia[J].Blood,2013,121(8):1384-1393.
[8]	PELKONEN O,TERRON A,HERNANDEZ A F,et al.Chemical exposure and infant leukaemia:development of an adverse outcome pathway (AOP) for aetiology and risk assessment research[J].Arch Toxicol,2017,91(8):2763-2780.
[9]	MARCOTTE E L,THOMOPOULOS T P,INFANTE——RIVARD C,et al.Caesarean delivery and risk of childhood leukaemia:a pooled analysis from the Childhood Leukemia International Consortium (CLIC)[J].Lancet Haematol,2016,3(4):e176-e185.
[10]	ZHANG M Y,LIU Y,LIU M,et al.UHPLC-QTOF/MS-based metabolomics investigation for the protective mechanism of Danshen in Alzheimer's disease cell model induced by Aβ_1-42[J].Metabolomics,2019,15(2):13.
[11]	ZHANG H,ZHAO Y H,XIA Z X,et al.Metabolic profiles revealed anti-ischemia-reperfusion injury of Yangxinshi tablet in Rats[J].J Ethnopharmacol,2018,214:124-133.
[12]	ARMITAGE E G,SOUTHAM A D.Monitoring cancer prognosis,diagnosis and treatment efficacy using metabolomics and lipidomics[J].Metabolomics,2016,12:146.
[13]	DUARTE I F,DIAZ S O,GIL A M.NMR metabolomics of human blood and urine in disease research[J].J Pharm Biomed Anal,2014,93:17-26.
[14]	刘悦,赵亮,李燕,等.肝细胞性肝癌代谢组学研究进展[J].药学实践杂志,2013,31(2):81-85.
[15]	IBARRA-GONZÁLEZ I,CRUZ-BAUTISTA I,BELLO-CHAVOLLA O Y,et al.Optimization of kidney dysfunction prediction in diabetic kidney disease using targeted metabolomics[J].Acta Diabetol,2018,55(11):1151-1161.
[16]	LE Y C,SHEN X Y,KANG H Y,et al.Accelerated,untargeted metabolomics analysis of cutaneous T-cell lymphoma reveals metabolic shifts in plasma and tumor adjacent skins of xenograft mice[J].J Mass Spectrom,2018,53(8):739.
[17]	XU J,LI J S,ZHANG R P,et al.Development of a metabolic pathway-based pseudo-targeted metabolomics method using liquid chromatography coupled with mass spectrometry[J].Talanta,2019,192:160-168.
[18]	AMBERG A,RIEFKE B,SCHLOTTERBECK G,et al.NMR and MSmethods for metabolomics[J].Methods Mol Biol,2017,1641:229-258.
[19]	PAPADIMITROPOULOS M P,VASILOPOULOU C G,MAGA-NTEVE C,et al.Untargeted GC-MS metabolomics[J].Methods Mol Biol,2018,1738:133-147.
[20]	LIU W J,SONG Q Q,CAO Y,et al.From ¹H NMR-based non-targeted to LC-MS-based targeted metabolomics strategy for in-depth chemome comparisons among four Cistanche species[J].J Pharm Biomed Anal,2019,162:16-27.
[21]	RAMAUTAR R,SOMSEN G W,DE JONG G J.CE-MS for metabolomics:Developments and applications in the period 2014-2016[J].Electrophoresis,2017,38(1):190-202.
[22]	YAN M,XU G W.Current and future perspectives of functional metabolomics in disease studies-A review[J].Anal Chim Acta,2018,1037:41-54.
[23]	LIU Y,LU S,ZHAO L,et al.Effects of glaucocalyxin A on human liver cancer cells as revealed by GC/MS- and LC/MS-based metabolic profiling[J].Anal Bioanal Chem,2018,410(14):3325-3335.
[24]	WU Q,ZHANG H,DING J R,et al.UPLC-QTOF MS——based serum metabolomic profiling analysis reveals the molecular perturbations underlying uremic pruritus[J].Biomed Res Int,2018,2018:4351674.
[25]	MAYER R L,SCHWARZMEIER J D,GERNER M C,et al.Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia[J].Mol Cell Proteomics,2018,17(2):290-303.
[26]	ALTMAN B J,STINE Z E,DANG C V.From Krebs to clinic:glutamine metabolism to cancer therapy[J].Nat Rev Cancer,2016,16(11):749.
[27]	AGATHOCLEOUS M,MEACHAM C E,BURGESS R J,et al.Ascorbate regulates haematopoietic stem cell function and leukaemogenesis[J].Nature,2017,549(7673):476-481.
[28]	OTTO A M.Warburg effect(s)-a biographical sketch of Otto Warburg and his impacts on tumor metabolism[J].Cancer Metab,2016,4:5.
[29]	VANDER HEIDEN M G,CANTLEY L C,THOMPSON C B.Understanding the Warburg effect:the metabolic requirements of cell proliferation[J].Science,2009,324(5930):1029-1033.
[30]	MUSHARRAF S G,SIDDIQUI A J,SHAMSI T,et al.SERUM metabolomics of acute lymphoblastic leukaemia and acute myeloid leukaemia for probing biomarker molecules[J].Hematol Oncol,2017,35(4):769-777.
[31]	GUO D M,LIU Q Q,LI B B,et al.Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21:A case report[J].Oncol Lett,2014,7(2):565-567.
[32]	YANG B Y,LI X L,YAO Y,et al.Metabolomics ofchronic myelogenous leukemia based on GC-MS[J].Zhongguo Shi Yan Xue Ye Xue Za Zhi,2017,25(6):1585-1591.
[33]	CHEN W L,WANG J H,ZHAO A H,et al.A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value[J].Blood,2014,124(10):1645-1654.
[34]	WANG Y H,ZHANG L M,CHEN W L,et al.Rapid diagnosis and prognosis of de novo acute myeloid leukemia by serum metabonomic analysis[J].J Proteome Res,2013,12(10):4393-4401.
[35]	ZHANG X L,YANG J,CHEN M J,et al.Metabolomics profiles delineate uridine deficiency contributes to mitochondria-mediated apoptosis induced by celastrol in human acute promyelocytic leukemia cells[J].Oncotarget,2016,7(29):46557-46572.
[36]	PERNICOVA I,KORBONITS M.Metformin:mode of action and clinical implications for diabetes and cancer[J].Nat Rev Endocrinol,2014,10(3):143-156.
[37]	MILLER R A,BIRNBAUM M J.An energetic tale of AMPK-independent effects of metformin[J].J Clin Invest,2010,120(7):2267-2270.
[38]	SCOTLAND S,SALAND E,SKULI N,et al.Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells[J].Leukemia,2013,27(11):2129-2138.
[39]	KOOPAL C,MARAIS A D,WESTERINK J,et al.Effect of adding bezafibrate to standard lipid-lowering therapy on post-fat load lipid levels in patients with familial dysbetalipoproteinemia.A randomized placebo-controlled crossover trial[J].J Lipid Res,2017,58(11):2180-2187.
[40]	SOUTHAM A D,KHANIM F L,HAYDEN R E,et al.Drugredeployment to kill leukemia and lymphoma cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids[J].Cancer Res,2015,75(12):2530-2540.
[41]	STÄUBERT C,BHUIYAN H,LINDAHL A,et al.Rewired metabolism in drug-resistant leukemia cells:a metabolic switch hallmarked by reduced dependence on exogenous glutamine[J].J Biol Chem,2015,290(13):8348-8359.

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Research progress of metabolomics in leukemia

doi: 10.3969/j.issn.1006-0111.2019.05.001

Abstract

References

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通讯作者: 陈斌, [email protected]

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