WAN Zhong, SUN Zhiguo, LU Ying, WANG Linhui. Preparation of cabazitaxel albumin nanoparticles and evaluation of its biocompatibility in vitro[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 246-248,259. doi: 10.3969/j.issn.1006-0111.2019.03.011
| Citation:
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WAN Zhong, SUN Zhiguo, LU Ying, WANG Linhui. Preparation of cabazitaxel albumin nanoparticles and evaluation of its biocompatibility in vitro[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 246-248,259. doi: 10.3969/j.issn.1006-0111.2019.03.011
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Preparation of cabazitaxel albumin nanoparticles and evaluation of its biocompatibility in vitro
- 1.
Department of Urology, Changzheng Hospital Affiliated to Naval Medical University, Shanghai 200438, China
- 2.
Department of Pharmaceutical Sciences, School of Pharmacy, Naval Medical University, Shanghai 200433, China
- Received Date: 2019-01-04
- Rev Recd Date:
2019-04-23
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Abstract
Objective To prepare cabazitaxel albumin nanoparticles(CBZ-BSA-Gd-NP) to reduce drug toxicity,and to evaluate its biocompatibility in vitro. Methods CBZ-BSA-Gd-NP was prepared by biomineralization method.The formulation process was optimized,and the properties such as particle size,Zeta potential and drug loading were characterized.The in vitro hemolysis characteristics were investigated. Results The encapsulation rate of the prepared nanoparticles was 63.04%,the drug loading was about 10.51%.The particle size was (166.1±4.7) nm with the PDI 0.256.The Zeta potential was (-18.14±1.16)mV.The hemolysis effect of CBZ-BSA-Gd-NP in vitro was significantly lower than that of cabazitaxel-Tween solution. Conclusion The preparation method of CBZ-BSA-Gd-NP in this study is simple,with high drug loading,uniform particle size and good blood compatibility in vitro,which will increase the safety for clinical use of the drug.
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