Anti-arthritis effects of matrine derivative in rats

XIE Fangyuan; WANG Tiantian; XU Weiheng; XIN Bao; ZHOU Xuwei; ZHANG Guoqing

doi:10.3969/j.issn.1006-0111.2019.03.010

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Objective To study the therapeutic effects of matrine derivative M19 on type Ⅱcollagen-induced arthritis (CIA) in rats. Methods Sixty rats were randomly divided into six groups:blank group,model group,indomethacin treatment group,M19 low,medium and high dose groups (2.5,5,10 mg/kg).The paw swelling,arthritis index (AI) and body weight were measured for CIA rats.The histopathological changes of joints and synovial tissue were observed by HE staining.The bone destruction was observed with micro-CT. Results Matrine derivative M19 reduced the paw swelling,increased body weight,inhibited inflammatory cell infiltration,ameliorated synovial tissue and bone destruction in CIA rats. Conclusion Matrine derivative M19 has the certain therapeutic effects on CIA.

Anti-arthritis effects of matrine derivative in rats

1. Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical University, Shanghai 200438, China

2. Department of Microbiology and Biochemical Pharmacy, School of Pharmacy, Naval Medical University, Shanghai 200433, China

Received Date: 2018-11-08

Rev Recd Date: 2018-12-19

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Abstract: Objective To study the therapeutic effects of matrine derivative M19 on type Ⅱcollagen-induced arthritis (CIA) in rats. Methods Sixty rats were randomly divided into six groups:blank group,model group,indomethacin treatment group,M19 low,medium and high dose groups (2.5,5,10 mg/kg).The paw swelling,arthritis index (AI) and body weight were measured for CIA rats.The histopathological changes of joints and synovial tissue were observed by HE staining.The bone destruction was observed with micro-CT. Results Matrine derivative M19 reduced the paw swelling,increased body weight,inhibited inflammatory cell infiltration,ameliorated synovial tissue and bone destruction in CIA rats. Conclusion Matrine derivative M19 has the certain therapeutic effects on CIA.

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Reference (17)

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Anti-arthritis effects of matrine derivative in rats

doi: 10.3969/j.issn.1006-0111.2019.03.010

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通讯作者: 陈斌, [email protected]

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