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Volume 37 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(2): 156-161,169

FAN Jiateng, LU Feng, XU Jiyang. Research on the inhibitory effect of amphotericin B against Candida albicans by D-SERS[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 156-161,169. doi: 10.3969/j.issn.1006-0111.2019.02.011
Citation: FAN Jiateng, LU Feng, XU Jiyang. Research on the inhibitory effect of amphotericin B against Candida albicans by D-SERS[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 156-161,169. doi: 10.3969/j.issn.1006-0111.2019.02.011
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Research on the inhibitory effect of amphotericin B against Candida albicans by D-SERS

doi: 10.3969/j.issn.1006-0111.2019.02.011

  • College of life science and technology, China Pharmaceutical University, Nanjing 210000, China

  • Received Date: 2018-05-05
  • Rev Recd Date: 2018-11-13
  • Objective To develop a rapid method to characterize the inhibitory effect of amphotericin B(AMB) against Candida albicans by dynamic surface enhanced Raman spectroscopy(D-SERS). Methods D-SERS were applied to analyze the effect of AMB on the Raman spectra of C.albicans by examining the relationship between the peak intensity ratio and the concentration of drug at Raman shift at 656 cm-1 and 729 cm-1 under different interaction time by a sensitive C.albicans and different AMB concentrations. Results The peak intensity ratio was negatively correlated with the concentration of AMB,which could be used to describe the inhibitory effect of AMB on C.albicans in a certain concentration and action time. Conclusion This method could characterize the inhibitory effect of AMB against C.albicans rapidly,which provided a simpler and faster detection method for characterizing more drug-pathogen interactions.
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    [13] ZHU Y,LI M,YU D,et al. A novel paper rag as ‘D-SERS’ substrate for detection of pesticide residues at various peels[J]. Talanta,2014,128:117-124.
    [14] YANG L,LI P,LIU H,et al. A dynamic surface enhanced Raman spectroscopy method for ultra-sensitive detection:from the wet state to the dry state[J]. Chem Soc Rev,2015,44(10):2837-2848.
    [15] TANG X,CAI W,YANG L,et al. Monitoring plasmon-driven surface catalyzed reactions in situ using time-dependent surface-enhanced Raman spectroscopy on single particles of hierarchical peony-like silver microflowers[J]. Nanoscale,2014,6(15):8612-8616.
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Research on the inhibitory effect of amphotericin B against Candida albicans by D-SERS

doi: 10.3969/j.issn.1006-0111.2019.02.011
  • College of life science and technology, China Pharmaceutical University, Nanjing 210000, China
  • Received Date: 2018-05-05
  • Rev Recd Date: 2018-11-13

Abstract: Objective To develop a rapid method to characterize the inhibitory effect of amphotericin B(AMB) against Candida albicans by dynamic surface enhanced Raman spectroscopy(D-SERS). Methods D-SERS were applied to analyze the effect of AMB on the Raman spectra of C.albicans by examining the relationship between the peak intensity ratio and the concentration of drug at Raman shift at 656 cm-1 and 729 cm-1 under different interaction time by a sensitive C.albicans and different AMB concentrations. Results The peak intensity ratio was negatively correlated with the concentration of AMB,which could be used to describe the inhibitory effect of AMB on C.albicans in a certain concentration and action time. Conclusion This method could characterize the inhibitory effect of AMB against C.albicans rapidly,which provided a simpler and faster detection method for characterizing more drug-pathogen interactions.

FAN Jiateng, LU Feng, XU Jiyang. Research on the inhibitory effect of amphotericin B against Candida albicans by D-SERS[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 156-161,169. doi: 10.3969/j.issn.1006-0111.2019.02.011
Citation: FAN Jiateng, LU Feng, XU Jiyang. Research on the inhibitory effect of amphotericin B against Candida albicans by D-SERS[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 156-161,169. doi: 10.3969/j.issn.1006-0111.2019.02.011
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