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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(2): 135-140,150

HAN Ling, FAN Li, ZHANG He, LÜ Lei, ZOU Hao, LU Ying. Formulation optimization for multi-purpose protective cream[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 135-140,150. doi: 10.3969/j.issn.1006-0111.2019.02.007
Citation: HAN Ling, FAN Li, ZHANG He, LÜ Lei, ZOU Hao, LU Ying. Formulation optimization for multi-purpose protective cream[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 135-140,150. doi: 10.3969/j.issn.1006-0111.2019.02.007
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Formulation optimization for multi-purpose protective cream

doi: 10.3969/j.issn.1006-0111.2019.02.007
  • 1.

    Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China

  • 2.

    Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai 200438, China

  • Received Date: 2018-10-29
  • Rev Recd Date: 2019-01-02
  • Objective To develop a multi-purpose protective cream with waterproof,sunscreen and jellyfish sting protection and optimize the formulation to provide good water resistance,high SPF,suitable viscosity and good stability. Methods The mass fraction of the film former VP/Hexadecene copolymer (Antaron V-216) in the formulation was optimized through the measurement of SPF value,critical wavelength and water resistance.Based on viscosity,centrifugal stability and freeze-thaw stability,the central composite design-response surface method was used to optimize the mass fraction of two emulsifiers and CaCl2 aqueous solution in the cream. Results When the film former Antaron V-216 has a mass fraction of 3%,the SPF value of the cream is significantly increased.When the mass fraction of emulsifier lauryl PEG/PPG-18/18 methicone (DC5200) is 0.76%,the mass fraction of emulsifier cetyl PEG/PPG-10/1 dimethicone (EM180) is 2.32% and the mass fraction of CaCl2 aqueous solution is 44.86%,the cream has suitable viscosity and good stability. Conclusion The optimized formulation has high water resistance and SPF value,suitable viscosity and good stability.
  • [1] 刘鹏,蔡杨.某特种部队海练期间伤病情况分析及对策[J].海军医学杂志,2016,37(4):296-298.
    [2] 卢畅,费文超,纪世召,等.海军某士官学校学员基层部队服役期间训练伤发生情况调查[J].解放军预防医学杂志,2017,35(1):16-18.
    [3] 王伟新,王玉梅,平安,等.海上训练防晒霜的研制与效果评价[J].解放军药学学报,2004,20(1):40-42.
    [4] BOULWARE D R.A randomized,controlled field trial for the prevention of jellyfish stings witha topical sting inhibitor[J].J Travel Med,2006,13(3):166-171.
    [5] 张智.水母蜇伤皮肤防护剂研究[D].上海:第二军医大学,2010.
    [6] LOTAN A.Method for inhibiting nematocyst discharge:US,US6406709[P].2002.
    [7] 唐俊敏.油包水乳化体系的配方设计及生产工艺研究(待续)[J].日用化学品科学,2006,29(10):39-41.
    [8] 唐俊敏.油包水乳化体系的配方设计及生产工艺研究(续前)[J].日用化学品科学,2006,29(11):34-37.
    [9] 董银卯.化妆品配方设计7步[M].北京:化学工业出版社,2016.
    [10] GASPAR L R,MAIA CAMPOS P M.Rheological behavior and the SPF of sunscreens[J].Int J Pharm,2003,250(1):35-44.
    [11] COUTEAU C,PAPARIS E,EL-BOURRY-ALAMI S,et al.Influence on SPF of the quantity of sunscreen product applied[J].Int J Pharm,2012,437(1-2):250-252.
    [12] OUYANG H.Evaluation of sunscreens using the critical wavelength test[J].Journal of the American Academy of Dermatology,2013,68(4):AB185.
    [13] 常明泉,王刚,汪依林,等.派莎防晒霜体外抗水效能的测定[J].中国药房,2010(33):3109-3110.
    [14] HEINRICH U,TRONNIER H,KOCKOTT D,et al.Comparison of sun protection factors determined by an invivo,and different invitro,methodologies:a study with 58 different commercially available sunscreen products[J].Int J Cosmet Sci,2004,26(2):79-89.
    [15] COLIPA In vitro UV protection method task force.COLIPA 2011:Method for in vitro determination of UVA protection[S].2011
    [16] 李竹,苏瑾,周世伟,等.防晒化妆品防水功效评价参数研究[J].上海预防医学杂志,2008(09):423-426.
    [17] 中国轻工业联合会.GB/T 29665-2013:护肤乳液[S].北京:中国标准出版社,2013.
    [18] 侯晓军,唐菱,周芃,等.星点设计-效应面法优化硼酸乳膏基质配方及质量控制[J].中国药师,2016,19(5):879-883.
    [19] 中国轻工业联合会.GB/T 13531.1-2008:化妆品通用检验方法pH值的测定[S].北京:中国标准出版社,2008.
    [20] 国家轻工业局行业管理司.QB/T2410-1998:防晒化妆品UVB区防晒效果的评价方法紫外吸光度法[S].北京:中国标准出版社,1998.
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Formulation optimization for multi-purpose protective cream

doi: 10.3969/j.issn.1006-0111.2019.02.007
  • 1. Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China
  • 2. Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai 200438, China
  • Received Date: 2018-10-29
  • Rev Recd Date: 2019-01-02

Abstract: Objective To develop a multi-purpose protective cream with waterproof,sunscreen and jellyfish sting protection and optimize the formulation to provide good water resistance,high SPF,suitable viscosity and good stability. Methods The mass fraction of the film former VP/Hexadecene copolymer (Antaron V-216) in the formulation was optimized through the measurement of SPF value,critical wavelength and water resistance.Based on viscosity,centrifugal stability and freeze-thaw stability,the central composite design-response surface method was used to optimize the mass fraction of two emulsifiers and CaCl2 aqueous solution in the cream. Results When the film former Antaron V-216 has a mass fraction of 3%,the SPF value of the cream is significantly increased.When the mass fraction of emulsifier lauryl PEG/PPG-18/18 methicone (DC5200) is 0.76%,the mass fraction of emulsifier cetyl PEG/PPG-10/1 dimethicone (EM180) is 2.32% and the mass fraction of CaCl2 aqueous solution is 44.86%,the cream has suitable viscosity and good stability. Conclusion The optimized formulation has high water resistance and SPF value,suitable viscosity and good stability.

HAN Ling, FAN Li, ZHANG He, LÜ Lei, ZOU Hao, LU Ying. Formulation optimization for multi-purpose protective cream[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 135-140,150. doi: 10.3969/j.issn.1006-0111.2019.02.007
Citation: HAN Ling, FAN Li, ZHANG He, LÜ Lei, ZOU Hao, LU Ying. Formulation optimization for multi-purpose protective cream[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 135-140,150. doi: 10.3969/j.issn.1006-0111.2019.02.007
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