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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(1): 69-73

SHI Lei, YE Jun, SONG Lei. Preparation and properties of alkalized shikonin liposome[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 69-73. doi: 10.3969/j.issn.1006-0111.2019.01.016
Citation: SHI Lei, YE Jun, SONG Lei. Preparation and properties of alkalized shikonin liposome[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 69-73. doi: 10.3969/j.issn.1006-0111.2019.01.016
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Preparation and properties of alkalized shikonin liposome

doi: 10.3969/j.issn.1006-0111.2019.01.016
  • 1.

    Shanghai Jingan Institute for Food and Drug Control, Shanghai 200435, China

  • 2.

    Tongren Hospital Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai 200050, China

  • Received Date: 2018-07-22
  • Rev Recd Date: 2018-11-12
  • Objective To study the preparation and properties of alkalized shikonin liposome. Methods Alkalized shikonin was purified from extracts of radix lithospermi with an alkali solution and acid formulation, and then the alkalized shikonin liposome was prepared by ethanol injection.The morphology, particle size and Zeta potential were determined, and the encapsulation efficiency and the in vitro release property were investigated.The content of L-shikonin was also measured by High Performance Liquid Chromatography. Results Alkalized shikonin liposome presented even sphere and normal distribution with particle size of 104.2 nm.The Zeta potential was-14.8 mV.L-shikonin was linear in the range of 5-50 mg/L with the correlation coefficient 0.999 9.The encapsulation efficiency was 43.67%.The final release rate was 65.82%. Conclusion Alkalized shikonin liposome was prepared successfully with good entrapment efficiency and in vitro release property.
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    [11] LI H,CHEN Y,DENG Y,et al.Effects of surface charge of low molecular weight heparin-modified cationic liposomes on drug efficacy and toxicity[J].Drug Dev Ind Pharm,2017,43(7):1163-1172.
    [12] 岳永阳.脂质体在中药制剂中的研究及应用进展[J].首都食品与医药,2015,22(12):100-102.
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    [14] 咎坷,苏蕊,滕爱君,等.新疆紫草HPLC特征图谱和紫草类药材6种萘醌类成分含量测定[J].药物分析杂志,2016,36(9):1526-1535.
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Preparation and properties of alkalized shikonin liposome

doi: 10.3969/j.issn.1006-0111.2019.01.016
  • 1. Shanghai Jingan Institute for Food and Drug Control, Shanghai 200435, China
  • 2. Tongren Hospital Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai 200050, China
  • Received Date: 2018-07-22
  • Rev Recd Date: 2018-11-12

Abstract: Objective To study the preparation and properties of alkalized shikonin liposome. Methods Alkalized shikonin was purified from extracts of radix lithospermi with an alkali solution and acid formulation, and then the alkalized shikonin liposome was prepared by ethanol injection.The morphology, particle size and Zeta potential were determined, and the encapsulation efficiency and the in vitro release property were investigated.The content of L-shikonin was also measured by High Performance Liquid Chromatography. Results Alkalized shikonin liposome presented even sphere and normal distribution with particle size of 104.2 nm.The Zeta potential was-14.8 mV.L-shikonin was linear in the range of 5-50 mg/L with the correlation coefficient 0.999 9.The encapsulation efficiency was 43.67%.The final release rate was 65.82%. Conclusion Alkalized shikonin liposome was prepared successfully with good entrapment efficiency and in vitro release property.

SHI Lei, YE Jun, SONG Lei. Preparation and properties of alkalized shikonin liposome[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 69-73. doi: 10.3969/j.issn.1006-0111.2019.01.016
Citation: SHI Lei, YE Jun, SONG Lei. Preparation and properties of alkalized shikonin liposome[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 69-73. doi: 10.3969/j.issn.1006-0111.2019.01.016
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