TAO Chun, YANG Huidan, HUANG Aiwen, CHEN Zhenzhen, ZHANG Qian, SONG Hongtao. Development and stability test of compound adapalene ointment[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 46-50,68. doi: 10.3969/j.issn.1006-0111.2019.01.011
| Citation:
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TAO Chun, YANG Huidan, HUANG Aiwen, CHEN Zhenzhen, ZHANG Qian, SONG Hongtao. Development and stability test of compound adapalene ointment[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 46-50,68. doi: 10.3969/j.issn.1006-0111.2019.01.011
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Development and stability test of compound adapalene ointment
- 1.
Department of Pharmacy, Fuzong Clinical Medical College of Fujian Medical University(Fuzhou General Hospital), Fuzhou 350025, China
- 2.
Department of Pharmacy, Fuzong Clinical Medical College of Fujian Medical University(Fuzhou General Hospital), Fuzhou 350025, China;School of Pharmacy, Fujian Medical University, Fuzhou 350108, China
- 3.
School of Pharmacy, Fujian Medical University, Fuzhou 350108, China
- Received Date: 2018-07-27
- Rev Recd Date:
2018-11-13
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Abstract
Objective To prepare, investigate and optimize the drug stability of compound adapalene ointment. Methods The ointment containing adapalene and mupirocin were prepared with PEG400 and PEG3350 as matrix.Stress test was used to evaluate and optimize the stability of drugs in the ointment.The drug stability was further tested by the acceleration test and long-term test. Results The raw adapalene was stable under high temperature, high humidity and strong light irradiation.The raw mupirocin was stable under high humidity and strong light irradiation, but was highly unstable under high temperature condition.Degradation of adapalene and mupirocin was found with pH ≤ 7.At pH 7.5, the best stability was achieved, with over 95% of the drugs remaining at day 10.Favorable ointment was prepared with PEG400:PEG3350=2:1.The drug stability was promoted by addition of 0.2% triethanolamine significantly.In the acceleration test and long-term test, the percentages of adapalene and mupirocin were above 95%. Conclusion The compound adapalene ointment was successfully prepared and the drug stability was excellent.
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