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Volume 36 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(6): 541-546

YANG Jie, WEN Hua, MA Bing, SUN Jing. Seven kinds of new oral anticoagulants for prevention of venous thromboembolism after total hip or knee arthroplasty: a net Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 541-546. doi: 10.3969/j.issn.1006-0111.2018.06.014
Citation: YANG Jie, WEN Hua, MA Bing, SUN Jing. Seven kinds of new oral anticoagulants for prevention of venous thromboembolism after total hip or knee arthroplasty: a net Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 541-546. doi: 10.3969/j.issn.1006-0111.2018.06.014
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Seven kinds of new oral anticoagulants for prevention of venous thromboembolism after total hip or knee arthroplasty: a net Meta-analysis

doi: 10.3969/j.issn.1006-0111.2018.06.014
  • 1.

    Department of Pneumology, The First Hospital, China Medical University, Shenyang 110001, China

  • 2.

    Department of Epidemiology, The First Hospital, China Medical University, Shenyang 110001, China

  • 3.

    Department of Dermatology, No. 463 Hospital of PLA, Shengyang 110042, China

  • Received Date: 2017-12-01
  • Rev Recd Date: 2018-08-25
  • Objective To assess the efficacy of seven kinds of new oral anticoagulants in prevention of venous thromboembolism in patients after total hip or knee replacement by a network Meta-analysis. Methods Randomized clinical trials in databases of CBM,Cochrane Library,Pubmed were searched. The quality of the included studies was assessed. Data were analyzed by Stata12.0 software,and mvmeta program package. Results 24 RCTs (in all 1 091 articles,40 001 patients) met the criteria. Prevention for VTE with prescribed dosage was evaluated. Following findings,directly,Rivaroxaban and Apixaban were more effective than low molecular weight heparin,results as (RR=0.56,95%CI:0.40-0.78),P<0.05;(RR=0.39,95%CI:0.24-0.63),P<0.05. The others compared with LMWH,P>0.05,had no statistical significance. Indirectly,these were all superior efficacy to placebo. Conclusion Grade rankings of efficacy for seven kinds of NOACs prevented VTE in patients after THR or TKR,Apixaban was best,followed by Rivaroxaban,Edoxaban,Ym150,TAK-442,dabigatran etexilate,Betrixaban.
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    [2] 邱贵兴.中国骨科大手术静脉血栓栓塞症预防指南[J].中华关节外科杂志[J/OL],2009,3(3):380.
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    [6] ERIKSSON B,DNHL OE,ROEENCHER N,et al.Oral dabigatran etexilate and subctltalleous enoxparin for the prevention of veneous thromboembolism after total knee replacement the RE-MODEL randomized trial[J].J Thromb Haemost,2007,5(11):2178-2185.
    [7] GINSBERG JS,DAVIDSON BL,COMP PC,et al.Oral thrombin inhibitor or dabigatan etexilate and North Ameriean enoxaparin regimen for prevention of venous thrombomembolism after knee arthroplasty surgery[J].J Arthroplasty,2009,24(1):1-9.
    [8] ERIKSSON BI,BORRIS LC,FRIEDMAN RJ,et al.Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty[J].N Engl J Med,2008,358(26):2765-2775.
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    [13] ERIKSSON BI,BORRIS L,DAHL OE,et al.For the ODIXa-HIP investigators study a randomised trial:oral direct factor Xa inhibition with BAY 59-7939 for the prevention of venous thromboembolism after total hip replacement[J]. Thromb Haemost,2006,4:121-128.
    [14] TURPIE, FISHER, BAUER,et al.BAY 59-7939 an oral direct factor Xa inhibitor for the prevention of venous thromboembolism in patients after total knee replacement a phase Ⅱ dose-ranging study[J].Thromb Haemost,2005,3(11):2479-2486.
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Seven kinds of new oral anticoagulants for prevention of venous thromboembolism after total hip or knee arthroplasty: a net Meta-analysis

doi: 10.3969/j.issn.1006-0111.2018.06.014
  • 1. Department of Pneumology, The First Hospital, China Medical University, Shenyang 110001, China
  • 2. Department of Epidemiology, The First Hospital, China Medical University, Shenyang 110001, China
  • 3. Department of Dermatology, No. 463 Hospital of PLA, Shengyang 110042, China
  • Received Date: 2017-12-01
  • Rev Recd Date: 2018-08-25

Abstract: Objective To assess the efficacy of seven kinds of new oral anticoagulants in prevention of venous thromboembolism in patients after total hip or knee replacement by a network Meta-analysis. Methods Randomized clinical trials in databases of CBM,Cochrane Library,Pubmed were searched. The quality of the included studies was assessed. Data were analyzed by Stata12.0 software,and mvmeta program package. Results 24 RCTs (in all 1 091 articles,40 001 patients) met the criteria. Prevention for VTE with prescribed dosage was evaluated. Following findings,directly,Rivaroxaban and Apixaban were more effective than low molecular weight heparin,results as (RR=0.56,95%CI:0.40-0.78),P<0.05;(RR=0.39,95%CI:0.24-0.63),P<0.05. The others compared with LMWH,P>0.05,had no statistical significance. Indirectly,these were all superior efficacy to placebo. Conclusion Grade rankings of efficacy for seven kinds of NOACs prevented VTE in patients after THR or TKR,Apixaban was best,followed by Rivaroxaban,Edoxaban,Ym150,TAK-442,dabigatran etexilate,Betrixaban.

YANG Jie, WEN Hua, MA Bing, SUN Jing. Seven kinds of new oral anticoagulants for prevention of venous thromboembolism after total hip or knee arthroplasty: a net Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 541-546. doi: 10.3969/j.issn.1006-0111.2018.06.014
Citation: YANG Jie, WEN Hua, MA Bing, SUN Jing. Seven kinds of new oral anticoagulants for prevention of venous thromboembolism after total hip or knee arthroplasty: a net Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 541-546. doi: 10.3969/j.issn.1006-0111.2018.06.014
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