Pharmacodynamics studies on Wentong Gao prepared with new process

HUANG Xiaobing; WU Xueru; WU Han; XIE Huamin

doi:10.3969/j.issn.1006-0111.2018.06.007

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Objective To study the analgesic, anti-inflammatory, reducing swelling and removing blood stasis effects of Wentong Gao prepared with the new process. Methods Acetic acid writhing test and formaldehyde induced mouse foot pain test were used to observe the analgesic effects of low, middle and high dose of Wentong Gao prepared with the new process and with the original process. The xylene-induced mouse ear edema test and Carrageenan-induced mouse paw swelling test were used to study the anti-inflammatory, swelling reducing effects of low, middle and high dose of Wentong Gao with new process and with the original process. Ecchymosis of guinea pigs were used to observe the blood stasis removing effects of low, middle and high dose of Wentong Gao prepared with new process and with the original process. Results Both the low and middle dose of Wentong Gao made with the new process and with the original process can significantly reduce the number of writhing reaction induced by acetic acid in mouse. The low, middle and high dose of Wentong Gao prepared with the new process can significantly reduce the swelling degree and swelling rate of xylene induced ear swelling in mouse. The low dose of Wentong Gao made with new process can significantly promote the ecchymosis area subsiding in guinea pigs. Conclusion Wentong Gao made with new process has good analgesic, anti-inflammatory, reducing swelling and removing blood stasis effects.

Pharmacodynamics studies on Wentong Gao prepared with new process

Affiliated Orthopedics and Traumatology Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510378, China

Received Date: 2018-03-02

Rev Recd Date: 2018-07-13

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Abstract: Objective To study the analgesic, anti-inflammatory, reducing swelling and removing blood stasis effects of Wentong Gao prepared with the new process. Methods Acetic acid writhing test and formaldehyde induced mouse foot pain test were used to observe the analgesic effects of low, middle and high dose of Wentong Gao prepared with the new process and with the original process. The xylene-induced mouse ear edema test and Carrageenan-induced mouse paw swelling test were used to study the anti-inflammatory, swelling reducing effects of low, middle and high dose of Wentong Gao with new process and with the original process. Ecchymosis of guinea pigs were used to observe the blood stasis removing effects of low, middle and high dose of Wentong Gao prepared with new process and with the original process. Results Both the low and middle dose of Wentong Gao made with the new process and with the original process can significantly reduce the number of writhing reaction induced by acetic acid in mouse. The low, middle and high dose of Wentong Gao prepared with the new process can significantly reduce the swelling degree and swelling rate of xylene induced ear swelling in mouse. The low dose of Wentong Gao made with new process can significantly promote the ecchymosis area subsiding in guinea pigs. Conclusion Wentong Gao made with new process has good analgesic, anti-inflammatory, reducing swelling and removing blood stasis effects.

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Pharmacodynamics studies on Wentong Gao prepared with new process

doi: 10.3969/j.issn.1006-0111.2018.06.007

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通讯作者: 陈斌, [email protected]

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