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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(6): 493-498

WU Wendan, LIANG Lin, TANG Ying, NI Hailai, GUO Meili. Pharmacodynamic study of total celosins on anti-hyperlipidemia[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 493-498. doi: 10.3969/j.issn.1006-0111.2018.06.004
Citation: WU Wendan, LIANG Lin, TANG Ying, NI Hailai, GUO Meili. Pharmacodynamic study of total celosins on anti-hyperlipidemia[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 493-498. doi: 10.3969/j.issn.1006-0111.2018.06.004
shu

Pharmacodynamic study of total celosins on anti-hyperlipidemia

doi: 10.3969/j.issn.1006-0111.2018.06.004
  • 1.

    Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Department of Preventive Health Care, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2018-03-29
  • Rev Recd Date: 2018-06-20
  • Objective To study the effect of total saponin (CES) on lipid metabolism in hyperlipidemic animals. Methods Golden hamster and rabbit hyperlipidemia animal models were established for this study.Both hyperlipidemia models were achieved by feeding high fat diet. The blood, hepatic lipid parameters and lipid peroxidation index were detected.Liver pathological changes were recorded. Results CES were orally administered to golden hamster hyperlipidemia model for two weeks at doses of 10-90 mg/kg. TC, TG and LDL-c were significantly reduced both in the serum and liver.In rabbit hyperlipidemia model, CES was orally administered at 6.0-24.0 mg/kg. Serum TC and LDL-c were reduced at day 10.Significant reduction of serum TC, LDL-c levels (P<0.01) and TG content (P<0.05) were observed after 20 and 30 days.This lipid-lowing effect was long lasting and stable. At the meantime, CES can also decrease the liver tissue TC, TG content (P<0.05) and MDA, LPS content (P<0.05). Pathological section showed that fat was significantly accumulated in the liver cell cytoplasm in rabbit model group. The liver cells were damaged. Large area of spotty necrosis was observed. Fat accumulation in the cytoplasm was significantly decreased in CES groups with dose dependent manner. With increased CES dose, liver damage was ameliorated. Conclusion CES can effectively reduce lipids in different animal hyperlipidemia models. This effect may be related to the decrease of the content of MDA and LPS in liver.
  • [1] Orsó E, Ahrens N, Kilálic D, et al. Familial hypercholesterolemia and lipoprotein(a) hyperlipidemia as independent and combined cardiovascular risk factors[J]. Atheroscler Suppl, 2009, 10(5):74-78.
    [2] Daniels SR, Greer FR. Lipid screening and cardiovascular health in childhood[J]. Pediatrics, 2008, 122(1):198-208.
    [3] Michaelson J, Hariharan V, Huang H. Hyperglycemic and hyperlipidemic conditions alter cardiac cell biomechanical properties[J]. Biophys J, 2014, 106(11):2322-2329.
    [4] Grundy SM. HMG-CoA reductase inhibitors for treatment of hypercholesterolemia[J]. N Engl J Med, 1988, 319(18):1222-1223.
    [5] 中国科学院植物志编委会, 中国植物志, 第25(2)卷[M].北京:科学出版社1979:200.
    [6] 国家药典委员会. 中华人民共和国药典(2010版)[M]. 北京:中国医药科技出版社, 2010:184.
    [7] Hase K, Kadota S, Basnet P, et al. Hepatoprotective effects of traditional medicine. Isolation of the active constituents from seeds of celosia argentea[J].Phytother Res, 1996, 10(5):387-392.
    [8] Hase K, Kadota S, BasnetP, et al. Protective effect of celosian, an acidic polysaccharide, on chemically and immunologically induced liver injuries[J]. Biol Pharm Bull. 1996, 19(4):567-572.
    [9] Hase K, Basnet P, Kadota S, et al. Immunostimulating activity of celosian, an antihepatotoxic polysaccharide isolated from celosia argentea[J]. Planta Med. 1997, 63(3):216-219.
    [10] Devhare SV, Nirmal SA, Rub RA, et al.Immunomodulating activity of celosia argentea Linn Aerial Parts[J].Lat Am J Pharm, 2011, 30(1):168-171.
    [11] Wu QB, WangY, GuoML. Triterpenoidsaponins from the seeds of celosia argentea and their anti-inflammatory and antitumor activities[J].Chem Pharm Bull. 2011, 59(5):666-671.
    [12] Vetrichelvan T, Jegadeesan M, Devi BA. Anti-diabetic activity of alcoholic extract of celosia argentea Linn. seeds in rats[J]. Biol Pharm Bull, 2002, 25(4):526-528.
    [13] 单俊杰, 任晋玮, 杨静, 等. 青葙子提取物降血糖活性的研究[J]. 中国药学杂志,2005, 40(16):1230-1233.
    [14] 黄秀榕, 祁明信, 汪朝勇, 等. 4种归肝经明目中药对晶状体上皮细胞凋亡相关基因Bcl-2和Bax的调控[J]. 中国临床药理学与治疗学, 2004,9(3):322-325.
    [15] 黄秀榕, 祁明信, 汪朝勇, 等. 四种归肝经明目中药防护晶状体氧化损伤和上皮细胞调亡的研究[J]. 中国临床药理学与治疗学, 2004,9(4):441-446.
    [16] Xue Q, Sun ZL, Guo ML, et al. Two new compounds from Semen celosiae and their protective effects against CCl4-induced hepatotoxicity[J]. Nat Prod Res, 2011, 25(8):772-780.
    [17] Sun ZL, Wang Y, Guo ML, et al. Two new hepaprotective saponins from Semen celosiae[J]. Fitoterapia, 2010, 81(5):375-380.
    [18] Wu QB, Wang Y, Liang L, et al. Novel triterpenoid saponins from the seeds of celosia argentea L[J]. Nat Prod Res, 2013, 27(15):1353-1360.
    [19] Chen RB, Zhang YY, He JM, et al. Simultaneous determination of two major triterpenoid saponins:Celosins I and Ⅱ in Celosiae Semen by HPLC-ELSD[J]. Chinese Herbal Medicines, 2015, 7(2):185-190.
    [20] 唐颖,梁琳,郭美丽. 青葙总皂苷对肝损伤保护作用的研究[J]. 药学实践杂志,2016. 34(3):201-205.
    [21] 高莹, 李可基, 唐世英, 等. 几种高脂血症动物模型的比较[J]. 卫生研究, 2002,31(2):97-99.
    [22] Xing WW, Wu JZ, Jia M, et al. Effects of polydatin from polygonum cuspidatum on lipid profile in hyperlipidemic rabbits[J]. Biomedecine&pharmacotherapie, 2009, 63(7):457-462.
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Pharmacodynamic study of total celosins on anti-hyperlipidemia

doi: 10.3969/j.issn.1006-0111.2018.06.004
  • 1. Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. Department of Preventive Health Care, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2018-03-29
  • Rev Recd Date: 2018-06-20

Abstract: Objective To study the effect of total saponin (CES) on lipid metabolism in hyperlipidemic animals. Methods Golden hamster and rabbit hyperlipidemia animal models were established for this study.Both hyperlipidemia models were achieved by feeding high fat diet. The blood, hepatic lipid parameters and lipid peroxidation index were detected.Liver pathological changes were recorded. Results CES were orally administered to golden hamster hyperlipidemia model for two weeks at doses of 10-90 mg/kg. TC, TG and LDL-c were significantly reduced both in the serum and liver.In rabbit hyperlipidemia model, CES was orally administered at 6.0-24.0 mg/kg. Serum TC and LDL-c were reduced at day 10.Significant reduction of serum TC, LDL-c levels (P<0.01) and TG content (P<0.05) were observed after 20 and 30 days.This lipid-lowing effect was long lasting and stable. At the meantime, CES can also decrease the liver tissue TC, TG content (P<0.05) and MDA, LPS content (P<0.05). Pathological section showed that fat was significantly accumulated in the liver cell cytoplasm in rabbit model group. The liver cells were damaged. Large area of spotty necrosis was observed. Fat accumulation in the cytoplasm was significantly decreased in CES groups with dose dependent manner. With increased CES dose, liver damage was ameliorated. Conclusion CES can effectively reduce lipids in different animal hyperlipidemia models. This effect may be related to the decrease of the content of MDA and LPS in liver.

WU Wendan, LIANG Lin, TANG Ying, NI Hailai, GUO Meili. Pharmacodynamic study of total celosins on anti-hyperlipidemia[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 493-498. doi: 10.3969/j.issn.1006-0111.2018.06.004
Citation: WU Wendan, LIANG Lin, TANG Ying, NI Hailai, GUO Meili. Pharmacodynamic study of total celosins on anti-hyperlipidemia[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 493-498. doi: 10.3969/j.issn.1006-0111.2018.06.004
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