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Volume 36 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(4): 365-368

CHANG Xinyu, GUO Guiming, LIU Yang, HAN Lijuan, CHE Xiaoping, FAN Zheng. Analysis and pharmaceutical care of the adverse reaction of cyclosporine induced by drug interaction[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 365-368. doi: 10.3969/j.issn.1006-0111.2018.04.018
Citation: CHANG Xinyu, GUO Guiming, LIU Yang, HAN Lijuan, CHE Xiaoping, FAN Zheng. Analysis and pharmaceutical care of the adverse reaction of cyclosporine induced by drug interaction[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 365-368. doi: 10.3969/j.issn.1006-0111.2018.04.018
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Analysis and pharmaceutical care of the adverse reaction of cyclosporine induced by drug interaction

doi: 10.3969/j.issn.1006-0111.2018.04.018

  • Department of Clinical Pharmacy, Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University, Beijing 100038, China

  • Received Date: 2017-09-11
  • Rev Recd Date: 2018-03-05
  • Objective To explore the role of clinical pharmacists in the clinical judgment and treatment of adverse drug reactions induced by drug interactions. Methods The correlation between cyclosporine and adverse effects of tremor in two hands were investigated by clinical pharmacists. The mechanism of the effect of anti-tuberculosis drugs on cyclosporine blood concentration was analyzed. Finally, suggestions on adverse reactions to drug interactions were given to assist clinicians in dealing with adverse reactions. Results The causes of adverse reactions were found out in time by the clinical pharmacists from their professional expertise. The clinical pharmacists assisted the doctor to adjust the patient's regimen. The patient's condition would be improved. Conclusion Clinical pharmacists could help doctors to ensure the safety of clinical medication through paying attention to adverse reactions.
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    [2] XIAOYAN PANG, YIFAN ZHANG, RUINA GAO, et al. Effects of rifampin and ketoconazole on pharmacokinetics of morinidazole in healthy Chinese subjects[J].Antimicrob Agents Chemother. 2014 Oct, 58(10):5987-5993.
    [3] WEN XI, WANG JS, NEUVONEN PJ, et al. Isoniazid is a mechanism-based inhibitor of cytochrome P4501A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes[J]. Eur J Clin Pharmacol,2002, 57(11):799-804.
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    [5] 程凯, 贾萍, 徐埏, 等. 72例环孢素A所致不良反应文献分析[J]. 中国药业, 2010, 19(1):36-37.
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    [10] CRETTOL S, VENETZ JM, AUBERT J, et al. CYP2A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement intransplant recipients[J]. Ther Drug Monit, 2008, 30(6):689-699.
    [11] 丁伶清, 田雪梅, 王彦娥, 等. 环孢素A药动学/药效学/不良反应的影响因素分析[J]. 中国医院药学杂志, 2016, 36(21):1935-1939.
    [12] WANG YI, WANG C, LI J, et al. Effect of genetic polymorphisms of CYP3A5 and MDR1 on cyclosporine concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem[J]. Eur J Clin Pharmacol. 2009 Mar; 65(3):239-247.
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Analysis and pharmaceutical care of the adverse reaction of cyclosporine induced by drug interaction

doi: 10.3969/j.issn.1006-0111.2018.04.018
  • Department of Clinical Pharmacy, Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University, Beijing 100038, China
  • Received Date: 2017-09-11
  • Rev Recd Date: 2018-03-05

Abstract: Objective To explore the role of clinical pharmacists in the clinical judgment and treatment of adverse drug reactions induced by drug interactions. Methods The correlation between cyclosporine and adverse effects of tremor in two hands were investigated by clinical pharmacists. The mechanism of the effect of anti-tuberculosis drugs on cyclosporine blood concentration was analyzed. Finally, suggestions on adverse reactions to drug interactions were given to assist clinicians in dealing with adverse reactions. Results The causes of adverse reactions were found out in time by the clinical pharmacists from their professional expertise. The clinical pharmacists assisted the doctor to adjust the patient's regimen. The patient's condition would be improved. Conclusion Clinical pharmacists could help doctors to ensure the safety of clinical medication through paying attention to adverse reactions.

CHANG Xinyu, GUO Guiming, LIU Yang, HAN Lijuan, CHE Xiaoping, FAN Zheng. Analysis and pharmaceutical care of the adverse reaction of cyclosporine induced by drug interaction[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 365-368. doi: 10.3969/j.issn.1006-0111.2018.04.018
Citation: CHANG Xinyu, GUO Guiming, LIU Yang, HAN Lijuan, CHE Xiaoping, FAN Zheng. Analysis and pharmaceutical care of the adverse reaction of cyclosporine induced by drug interaction[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 365-368. doi: 10.3969/j.issn.1006-0111.2018.04.018
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