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Volume 36 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(3): 270-273

XUAN Weidong, FAN Zhengping, HU Shuigen, XU Dedong. Study on hydrophilic chemical constituents from Thesium Chinensis Turcz[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 270-273. doi: 10.3969/j.issn.1006-0111.2018.03.017
Citation: XUAN Weidong, FAN Zhengping, HU Shuigen, XU Dedong. Study on hydrophilic chemical constituents from Thesium Chinensis Turcz[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 270-273. doi: 10.3969/j.issn.1006-0111.2018.03.017
shu

Study on hydrophilic chemical constituents from Thesium Chinensis Turcz

doi: 10.3969/j.issn.1006-0111.2018.03.017

  • No. 411 Hospital of PLA, Shanghai 200081, China

  • Received Date: 2017-12-04
  • Rev Recd Date: 2018-01-17
  • Objective To investigate the hydrophilic chemical constituents from Thesium Chinensis Turcz. Methods The water extract of Thesium Chinensis Turcz. was adsorbed onto AB-8 resin column and eluted with 50% ethanol to give the hydrophilic portion TT50. TT50 was further separated and purified by repeated column chromatography on silica gel,Sephadex LH-20. The structures of these purified compounds were identified by NMR spectral analysis and comparison with the reported data. Results Six compounds were isolated and identified as kaempferol ( 1 ),kaempferol-3-O-glucoside ( 2 ),kaepmferol-3,7-di-O-β-D-glucopyranoside ( 3 ),kaempferol-3-O-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside ( 4 ),kaemperol-3-O-α-L-rhamnopyranosyl(1→2)-[6-O-acetyl]-β-D-glucopyranoside ( 5 ),rutinoside ( 6 ). Conclusion The main constituents of TT50 were kaempferol glycosides. Compounds 4 and 5 were isolated from this plant for the first time.
  • [1] Parveen Z,Deng Y,Saeed MK,et al. Antiinflammatory and analgesic activities of Thesium chinense Turcz extracts and its major flavonoids,kaempferol and kaempferol-3-O-glucoside[J]. Yakugaku Zasshi,2007,127(8):1275-1279.
    [2] 宣伟东,唐大海,卞俊,等. 百蕊草对阿霉素肾病大鼠治疗作用的实验研究[J].药学实践杂志,2012,30(6):443-446.
    [3] 闫俊,唐大海,宣伟东,等. 百蕊草提取物对免疫球蛋白A肾病模型大鼠的治疗作用[J].药学实践杂志,2015,33(1):28-31.
    [4] Lee IK,Kim KH,Choi SU,et al. Photochemical constituents of Thesium Chinense Turcz and their cytotoxic activities in vitro[J]. Nat Prod Sci,2009,15(4):246-249.
    [5] Wu H,Dushenkov S,Ho CT. et al. Novel acetylated flavonoid glycosides from the leaves of Allium ursinum [J]. Food Chem,2009,115(2):592-595.
    [6] Norbaek R,Kondo T. Flavonol glycosides from flowers of Crocus speciosus and C. antalyensis[J]. Photochemistry,1999,51(8):1113-1119.
    [7] 邹懿,洪敏,杨笑芳. 百蕊草化学成分分离[J].中国实验方剂学杂志,2016,22(7):74-77
    [8] 鲁云霞,汪俊松. 百蕊草的化学成分研究[J].中草药,2004,35(5):491-493.
    [9] 刘洋,邓玉林,张经华,等.百蕊草黄酮类化合物研究[J].中药材,2009,32(4):518-520.
    [10] 安徽省医学科学研究所植化室百蕊草组.百蕊草有效成分的化学研究(第一报)[J].中草药通讯,1976,8:6-12.
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Study on hydrophilic chemical constituents from Thesium Chinensis Turcz

doi: 10.3969/j.issn.1006-0111.2018.03.017
  • No. 411 Hospital of PLA, Shanghai 200081, China
  • Received Date: 2017-12-04
  • Rev Recd Date: 2018-01-17

Abstract: Objective To investigate the hydrophilic chemical constituents from Thesium Chinensis Turcz. Methods The water extract of Thesium Chinensis Turcz. was adsorbed onto AB-8 resin column and eluted with 50% ethanol to give the hydrophilic portion TT50. TT50 was further separated and purified by repeated column chromatography on silica gel,Sephadex LH-20. The structures of these purified compounds were identified by NMR spectral analysis and comparison with the reported data. Results Six compounds were isolated and identified as kaempferol ( 1 ),kaempferol-3-O-glucoside ( 2 ),kaepmferol-3,7-di-O-β-D-glucopyranoside ( 3 ),kaempferol-3-O-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside ( 4 ),kaemperol-3-O-α-L-rhamnopyranosyl(1→2)-[6-O-acetyl]-β-D-glucopyranoside ( 5 ),rutinoside ( 6 ). Conclusion The main constituents of TT50 were kaempferol glycosides. Compounds 4 and 5 were isolated from this plant for the first time.

XUAN Weidong, FAN Zhengping, HU Shuigen, XU Dedong. Study on hydrophilic chemical constituents from Thesium Chinensis Turcz[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 270-273. doi: 10.3969/j.issn.1006-0111.2018.03.017
Citation: XUAN Weidong, FAN Zhengping, HU Shuigen, XU Dedong. Study on hydrophilic chemical constituents from Thesium Chinensis Turcz[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 270-273. doi: 10.3969/j.issn.1006-0111.2018.03.017
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