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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(3): 265-269,288

ZHAO Xin, SHAO Wei, ZHANG Peng, XU Zhiwei. Establishment of quality standards for Xiangsu Weitong Capsule[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 265-269,288. doi: 10.3969/j.issn.1006-0111.2018.03.016
Citation: ZHAO Xin, SHAO Wei, ZHANG Peng, XU Zhiwei. Establishment of quality standards for Xiangsu Weitong Capsule[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 265-269,288. doi: 10.3969/j.issn.1006-0111.2018.03.016
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Establishment of quality standards for Xiangsu Weitong Capsule

doi: 10.3969/j.issn.1006-0111.2018.03.016
  • 1.

    Institute for Drug and Instrument Control of Shenyang Military Region, Shenyang 110026, China

  • 2.

    Center for Disease Control and Prevention of Shenyang Military Region, Shenyang 110036, China

  • Received Date: 2017-09-12
  • Rev Recd Date: 2018-03-30
  • Objective To establish the quality standard for Xiangsu Weitong capsule. Methods Radixet rhizoma glycyrrhizae,rhizoma corydalis,poria,rhizoma cyperi were identified by TLC and the contents of baicalin were determined by RP-HPLC. Chromatography conditions were Welchrom C18 (4.6 mm×250 mm, 5 μm) column. The mobile phase was acetonitrile-0.1% phosphoric acid(40:60). UV detection wavelength was set at 280 nm and the column temperature was 30℃ with the flow rate of 1.0 ml/min. Results The method of TLC had good resolution with clear spots and negative control showed no interference. The good linearity was obtained within the range of 1-80 μg/ml(r=0.999 9) for Tetrahydropalmatine hydrochloride and the average recovery was 99.1% (RSD=1.28%,n=6). Conclusion The method was simple, accurate and sensitive which could be applied in the quality control of Xiangsu Weitong capsule.
  • [1] 沈阳军区联勤部卫生部非标准制剂质量标准SYWS-F41003-2012Z[S].沈阳,2012.
    [2] 范卓文,武斌,刘国臣,等.延胡索药理研究及临床应用进展[J].黑龙江医药,2007,38(5):522-524.
    [3] 黄欢,张晓瑜,张宏,等.HPLC法同时测定秦艽中龙胆苦苷及元胡中延胡索乙素的含量[J].药物分析杂志,2007,17(7):1029-1032.
    [4] 王光发,廖正根,梁新丽,等.HPLC法同时测定元胡止痛片中三种活性成分的含量[J].中国药房,2009,20(9):672-674.
    [5] 苏莉,索志荣,包莉萍,等.湖北延胡索中延胡索乙素含量测定方法研究[J].广州化工,2015(7):118-120.
    [6] 国家药典委员会.中华人民共和国药典(一部):2015年版[S].北京:中国医药科技出版社,2015:342-343.
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Establishment of quality standards for Xiangsu Weitong Capsule

doi: 10.3969/j.issn.1006-0111.2018.03.016
  • 1. Institute for Drug and Instrument Control of Shenyang Military Region, Shenyang 110026, China
  • 2. Center for Disease Control and Prevention of Shenyang Military Region, Shenyang 110036, China
  • Received Date: 2017-09-12
  • Rev Recd Date: 2018-03-30

Abstract: Objective To establish the quality standard for Xiangsu Weitong capsule. Methods Radixet rhizoma glycyrrhizae,rhizoma corydalis,poria,rhizoma cyperi were identified by TLC and the contents of baicalin were determined by RP-HPLC. Chromatography conditions were Welchrom C18 (4.6 mm×250 mm, 5 μm) column. The mobile phase was acetonitrile-0.1% phosphoric acid(40:60). UV detection wavelength was set at 280 nm and the column temperature was 30℃ with the flow rate of 1.0 ml/min. Results The method of TLC had good resolution with clear spots and negative control showed no interference. The good linearity was obtained within the range of 1-80 μg/ml(r=0.999 9) for Tetrahydropalmatine hydrochloride and the average recovery was 99.1% (RSD=1.28%,n=6). Conclusion The method was simple, accurate and sensitive which could be applied in the quality control of Xiangsu Weitong capsule.

ZHAO Xin, SHAO Wei, ZHANG Peng, XU Zhiwei. Establishment of quality standards for Xiangsu Weitong Capsule[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 265-269,288. doi: 10.3969/j.issn.1006-0111.2018.03.016
Citation: ZHAO Xin, SHAO Wei, ZHANG Peng, XU Zhiwei. Establishment of quality standards for Xiangsu Weitong Capsule[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 265-269,288. doi: 10.3969/j.issn.1006-0111.2018.03.016
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