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Volume 36 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(3): 260-264,281

WAN Suxin, XIANG Yi, LUO Yaling. The efficacy and safety evaluation of donepezil combined with memantine for the treatment of Alzheimer's disease[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 260-264,281. doi: 10.3969/j.issn.1006-0111.2018.03.015
Citation: WAN Suxin, XIANG Yi, LUO Yaling. The efficacy and safety evaluation of donepezil combined with memantine for the treatment of Alzheimer's disease[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 260-264,281. doi: 10.3969/j.issn.1006-0111.2018.03.015
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The efficacy and safety evaluation of donepezil combined with memantine for the treatment of Alzheimer's disease

doi: 10.3969/j.issn.1006-0111.2018.03.015
  • 1.

    Chongqing Three Gorges Central Hospital, Chongqing, 404000 China

  • 2.

    Department of Mathematics, School of Medical Information, Chongqing Medical University, Chongqing, 40016 China

  • Received Date: 2017-07-27
  • Rev Recd Date: 2018-02-10
  • Objective To evaluate the efficacy and safety of donepezil combined with memantine in the treatment of Alzheimer's disease and provide a guidance for the proper clinical use of those medications. Methods The literatures published from 2014 to 2016 in CNKI/VIP/WanFang Med-online/CBM and other databases were collected. Screening and quality evaluation were carried out with include and exclude standard. The software RevMan 5.3 was used for data analysis. Results Eighteen studies included are randomized controlled trials with 900 cases in study group and 896 cases in control group. The combined results showed that MMSE, NPI and BEHAVE -AD of the combination therapy were superior to those of monotherapy group. There is no significant difference in ADL and ADAS-Cog. Conclusion The combination therapy was better than monotherapy both in mental state and pathological behavior. The clinical application of those medications should be based on the specific conditions of individual patient.
  • [1] Gauthier S, Loft H, Cummings J. Improvement in behavioural symptoms in patients with moderate to severe Alzheimer's disease by memantine:a pooled data analysis[J]. Int J Geriatr Psychiatry, 2008,23(5):537-545.
    [2] 王戈. 盐酸美金刚联合多奈哌齐治疗中重度阿尔茨海默病精神行为障碍的Meta分析[D]. 青岛:山东大学, 2016.
    [3] 张晓燕. 探讨乙酰胆碱酶抑制剂类药物联合盐酸美金刚治疗老年痴呆(AD)患者的临床疗效[J]. 中国医药指南, 2015,13(11):92-93.
    [4] 张申. 联用盐酸多奈哌齐和盐酸美金刚治疗阿尔茨海默病的效果评价[J]. 当代医药论丛, 2016(12):178-179.
    [5] 张大为. 胆碱酯酶抑制剂三联疗法用于血管性痴呆治疗的回顾性分析[J]. 社区医学杂志, 2016,14(13):50-51.
    [6] 岳莉莉,左文秀,汪辉耀,等. 盐酸多奈哌齐联合美金刚对阿尔茨海默病患者认知及生活能力改善的研究[J]. 疑难病杂志, 2015,14(10):1020-1022.
    [7] 俞厚明,俞一超,张小平. 小剂量多奈哌齐与美金刚合用治疗阿尔茨海默病的有效性及安全性[J]. 中国老年学杂志, 2015. 35(17):4848-4850.
    [8] 魏悯. 多奈哌齐联合美金刚对阿尔茨海默病患者认知功能与行为能力的作用及安全性[J]. 武汉大学学报(医学版), 2016,37(3):461-463.
    [9] 王雪. 多奈哌齐联合盐酸美金刚治疗阿尔茨海默病的临床研究[J]. 中国继续医学教育, 2015,7(14):138-139.
    [10] 谭红. 美金刚与多奈哌齐联合应用治疗高龄阿尔茨海默病52例临床疗效分析[J]. 中国现代药物应用, 2016,10(5):105-106.
    [11] 孙红生,任邵新,丛向阳. 盐酸多奈哌齐联合盐酸美金刚对改善阿尔茨海默病认知功能和精神行为的作用[J].中国基层医药, 2015(10):1534-1539.
    [12] 邵红艳. 盐酸美金刚对老年痴呆患者认知功能及行为异常的效果分析[J]. 中国药业, 2015,24(10):49-51.
    [13] 彭乐,陈发秀. 美金刚联合多奈哌齐治疗中重度阿尔茨海默病的临床研究[J]. 中国老年保健医学, 2015,13(2):75-77.
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    [15] 李瑞. 多奈哌齐联合美金刚治疗中重度老年阿尔茨海默病的临床疗效[J]. 中国现代药物应用, 2016,10(15):115-116.
    [16] 李晴,秦琴保,于小琪. 多奈哌齐联合美金刚治疗40例阿尔茨海默病高龄患者的临床效果观察[J]. 现代医院, 2016,16(6):812-814.
    [17] 焦迎宾. 盐酸多奈哌齐与盐酸美金刚联合治疗阿尔茨海默病患者的临床疗效[J]. 中国药物经济学, 2016(12):73-74.
    [18] 蒋志宏,蔡鸣,谷新医,等. 美金刚联合盐酸多奈哌齐治疗阿尔茨海默病疗效研究[J]. 中国药业, 2016,25(14):55-58.
    [19] 霍江涛,张小乔,严洁. 美金刚联合多奈哌齐治疗中重度阿尔茨海默病的效果观察[J]. 中国综合临床, 2015,31(11):969-971.
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The efficacy and safety evaluation of donepezil combined with memantine for the treatment of Alzheimer's disease

doi: 10.3969/j.issn.1006-0111.2018.03.015
  • 1. Chongqing Three Gorges Central Hospital, Chongqing, 404000 China
  • 2. Department of Mathematics, School of Medical Information, Chongqing Medical University, Chongqing, 40016 China
  • Received Date: 2017-07-27
  • Rev Recd Date: 2018-02-10

Abstract: Objective To evaluate the efficacy and safety of donepezil combined with memantine in the treatment of Alzheimer's disease and provide a guidance for the proper clinical use of those medications. Methods The literatures published from 2014 to 2016 in CNKI/VIP/WanFang Med-online/CBM and other databases were collected. Screening and quality evaluation were carried out with include and exclude standard. The software RevMan 5.3 was used for data analysis. Results Eighteen studies included are randomized controlled trials with 900 cases in study group and 896 cases in control group. The combined results showed that MMSE, NPI and BEHAVE -AD of the combination therapy were superior to those of monotherapy group. There is no significant difference in ADL and ADAS-Cog. Conclusion The combination therapy was better than monotherapy both in mental state and pathological behavior. The clinical application of those medications should be based on the specific conditions of individual patient.

WAN Suxin, XIANG Yi, LUO Yaling. The efficacy and safety evaluation of donepezil combined with memantine for the treatment of Alzheimer's disease[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 260-264,281. doi: 10.3969/j.issn.1006-0111.2018.03.015
Citation: WAN Suxin, XIANG Yi, LUO Yaling. The efficacy and safety evaluation of donepezil combined with memantine for the treatment of Alzheimer's disease[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 260-264,281. doi: 10.3969/j.issn.1006-0111.2018.03.015
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